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Cited by 229Peroxisome Proliferator-Activated ReceptorsBreast Cancer Treatment StudiesCancer, Lipids, and Metabolism

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Use of the Peroxisome Proliferator-Activated Receptor (PPAR) γ Ligand Troglitazone as Treatment for Refractory Breast Cancer: A Phase II Study

Burstein, Harold J., Demetri, George D., Mueller, Elisabetta, Sarraf, Pasha, Spiegelman, Bruce M., Winer, Eric P.·2003·Breast Cancer Research and Treatment
DOI 10.1023/a:1024038127156
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Abstract

Purpose To evaluate the therapeutic effects of the peroxisome proliferator-activated receptor (PPAR) gamma activating ligand, troglitazone, in patients with refractory metastatic breast cancer.Experimental design Patients with advanced breast cancer refractory to at least one chemotherapy regimen (ER negative tumors) or two hormonal regimens (ER positive tumors) were treated with troglitazone at 800 mg p.o. QD until disease progression, to determine the percentage of patients free of progression at 6 months. Tumor response, toxicity, and changes in serum tumor markers (CEA, CA27.29) that might reflect alteration in tumor differentiation, were also examined.Results Twenty-two patients were enrolled before suspension of protocol accrual and treatment when troglitazone was withdrawn from commercial availability following FDA warnings on hepatic toxicity. No objective responses (CR or PR) were observed; only three patients had SD at 8 weeks. Patients came off study for PD (16), DLT (1), FDA withdrawal (2), or other (3) reasons. No patients took troglitazone for more than 20 weeks; all had experienced disease progression or began other systemic therapy within 6 months. All patients with elevated serum tumor markers (CEA and CA27.29) at baseline had rising tumor markers within 8 weeks.Conclusions While clinical trials among different patient populations might uncover subtle effects on tumor differentiation, PPARgamma activation by troglitazone has little apparent clinical value among patients with treatment-refractory metastatic breast cancer.

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  1. Demetri GD, Spiegelman B, Fletcher CD et al.: Differentiation of liposarcomas in patients treated with PPAR γ ligand troglitazone: documentation of biological activity in myxoid/ round cell and pleomorphic subtypes. Proc AmSoc Clin Oncol 18: 535a, 1999 (abstract 2064)

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Metadata

Authors
Burstein, H. J., Demetri, G. D., Mueller, E., Sarraf, P., Spiegelman, B. M., & Winer, E. P.
Affiliations
  • Dana-Farber Cancer Institute (US)
  • Brigham and Women's Hospital (US)
ORCID
Venue
Breast Cancer Research and Treatment
Publisher
Springer Science and Business Media LLC
Published
2003-06
Volume
79
Issue
3
Pages
391-397
ISSN
  • 0167-6806 (ISSN-L)
  • 1573-7217
DOI
10.1023/a:1024038127156
OpenAlex
W1968980738
Cited by
228
References
21
Citations by year
2026: 2 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 14 · 2020: 5 · 2019: 7 · 2018: 13 · 2017: 11 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 10 · 2012: 18
FWCI
4.25
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Breast Cancer Research and Treatment (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
troglitazone, PPARγ agonists, metastatic breast cancer, estrogen receptor-negative breast cancer, estrogen receptor-positive breast cancer, tumor markers, CEA, CA 27.29, tumor differentiation, drug toxicity, disease progression
MeSH terms
Troglitazone, Administration, Oral, Adult, Aged, Antineoplastic Agents, Breast Neoplasms, Chromans, Female, Humans, Liver, Middle Aged, Neoplasm Invasiveness, Thiazoles, Treatment Outcome, Disease Progression, Thiazolidinediones

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