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Cited by 53Antioxidant Activity and Oxidative StressNatural Antidiabetic Agents StudiesAldose Reductase and Taurine

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Beneficial effect of vitamin E on the metabolic parameters of diabetic rats

Al Shamsi, Maryam S., Amin, Amr, Adeghate, Ernest·2004·Molecular and Cellular Biochemistry
DOI 10.1023/b:mcbi.0000028735.79172.9b
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Abstract

The role of vitamin E in the pathogenesis of diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin E on some of the metabolic parameters of experimental diabetic rats. Diabetes was induced by intraperitoneal injection of streptozotocin (60 mg/kg body weight at 12 weeks of age). Vitamin E (0.2, 0.4, 0.8 mg/kg body weight) was administered orally for a period of 3 weeks to normal and diabetic Wistar rats. In some experiments, Vitamin E was given either before or after the induction of diabetes mellitus. Blood glucose level and weight were recorded for each rat in different groups on a weekly basis. Oral glucose tolerance test (OGTT) was performed on fasted normal, diabetic and vitamin E treated rats at the end of the experiment. Vitamin E significantly (p < 0.01) reduced blood glucose levels in experimental diabetes mellitus at all doses as compared to untreated rats. Vitamin E induced weight loss in normal as well as in diabetic rats. The beneficial effect of vitamin E on the hyperglycaemia of diabetic rats was dose-dependent. Moreover, vitamin E also improved OGTT in diabetic rats compared to untreated diabetics. In conclusion, vitamin E may play a role in glucose metabolism and thus be a useful adjuvant therapy in type I diabetes.

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Crossref · 10.1023/b:mcbi.0000028735.79172.9b

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Metadata

Authors
Al Shamsi, M. S., Amin, A., & Adeghate, E.
Affiliations
United Arab Emirates University (AE)
Corresponding author
Adeghate, Ernest
ORCID
Venue
Molecular and Cellular Biochemistry
Publisher
Springer Science and Business Media LLC
Published
2004-06
Volume
261
Issue
1
Pages
35-42
ISSN
  • 0300-8177 (ISSN-L)
  • 1573-4919
DOI
10.1023/b:mcbi.0000028735.79172.9b
OpenAlex
W1986942886
Cited by
53
References
35
Citations by year
2026: 2 · 2024: 3 · 2023: 11 · 2022: 10 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
0.21
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular and Cellular Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords
vitamin E, diabetes mellitus, streptozotocin-induced diabetes, blood glucose, glucose tolerance, hyperglycemia, weight loss, glucose metabolism, type 1 diabetes, adjuvant therapy, dose-dependent effects
MeSH terms
Animals, Antioxidants, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Glucose Tolerance Test, Male, Vitamin E, Rats, Wistar, Rats

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