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Cited by 204HIV/AIDS Research and InterventionsMedication Adherence and ComplianceHIV/AIDS drug development and treatment

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Factors Influencing Medication Adherence Beliefs and Self-Efficacy in Persons Naive to Antiretroviral Therapy: A Multicenter, Cross-Sectional Study

Reynolds, Nancy R., Testa, Marcia A., Marc, Linda G., Chesney, Margaret A., Neidig, Judith L., Smith, Scott R., Vella, Stefano, Robbins, Gregory K., Protocol Teams of ACTG 384, ACTG 731, and A5031s·2004·AIDS and Behavior
DOI 10.1023/b:aibe.0000030245.52406.bb
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Abstract

It is widely recognized that adherence to antiretroviral therapy is critical to long-term treatment success, yet rates of adherence to antiretroviral medications are frequently subtherapeutic. Beliefs about antiretroviral therapy and psychosocial characteristics of HIV-positive persons naive to therapy may influence early experience with antiretroviral medication adherence and therefore could be important when designing programs to improve adherence to antiretroviral therapy. As part of a multicenter AIDS Clinical Trial Group (ACTG 384) study, 980 antiretroviral-naive subjects (82% male, 47% White, median age 36 years, and median CD4 cell count 278 cells/mm3) completed a self-administered questionnaire prior to random treatment assignment of initial antiretroviral medications. Measures of symptom distress, general health and well-being, and personal and situational factors including demographic characteristics, social support, self-efficacy, depression, stress, and current adherence to (nonantiretroviral) medications were recorded. Associations among variables were explored using correlation and regression analyses. Beliefs about the importance of antiretroviral adherence and ability to take antiretroviral medications as directed (adherence self-efficacy) were generally positive. Fifty-six percent of the participants were "extremely sure" of their ability to take all medications as directed and 48% were "extremely sure" that antiretroviral nonadherence would cause resistance, but only 37% were as sure that antiretroviral therapy would benefit their health. Less-positive beliefs about antiretroviral therapy adherence were associated with greater stress, depression, and symptom distress. More-positive beliefs about antiretroviral therapy adherence were associated with better scores on health perception, functional health, social-emotional-cognitive function, social support, role function, younger age, and higher education (r values = 0.09-0.24, all p < .001). Among the subset of 325 participants reporting current use of medications (nonantiretrovirals) during the prior month, depression was the strongest correlate of nonadherence ( r = 0.33, p < .001). The most common reasons for nonadherence to the medications were "simply forgot" (33%), "away from home" (27%), and "busy" (26%). In conclusion, in a large, multicenter survey, personal and situational factors, such as depression, stress, and lower education, were associated with less certainty about the potential for antiretroviral therapy effectiveness and one's perceived ability to adhere to therapy. Findings from these analyses suggest a role for baseline screening for adherence predictors and focused interventions to address modifiable factors placing persons at high risk for poor adherence prior to antiretroviral treatment initiation.

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Research works printed but not linked: 2

  1. Reynolds, N. R., Testa, M. A., Su, M., Chesney, M. A., and Robbins, G. K. for the Protocol Teams of ACTG 384. (July, 2003). Baseline predictors of adherence and regimen failure in treatment naëve HIV+; subjects (ACTG 384). Presented at the 2nd IAS Conference on HIV Pathogenesis and Treatment, Paris.
  2. SPSS Inc. (2002). SPSS version 11.5. Chicago: Author.

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Metadata

Authors
Reynolds, N. R., Testa, M. A., Marc, L. G., Chesney, M. A., Neidig, J. L., Smith, S. R., Vella, S., Robbins, G. K., & Protocol Teams of ACTG 384, A. 7.
Affiliations
  • The Ohio State University (US)
  • Harvard University (US)
  • University of California, San Francisco (US)
  • University of North Carolina at Chapel Hill (US)
  • Istituto Superiore di Sanità (IT)
  • Massachusetts General Hospital (US)
Corresponding author
Reynolds, Nancy R.
ORCID
Venue
AIDS and Behavior
Publisher
Springer Science and Business Media LLC
Published
2004-06
Volume
8
Issue
2
Pages
141-150
ISSN
  • 1090-7165 (ISSN-L)
  • 1573-3254
DOI
10.1023/b:aibe.0000030245.52406.bb
OpenAlex
W2015240464
Cited by
204
References
35
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 1 · 2017: 6 · 2016: 15 · 2015: 13 · 2014: 20 · 2013: 9 · 2012: 11
FWCI
8.68
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • AIDS and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI38858, U01AI025924, AI2-7659, AI 25924, U01AI025868, U01AI038858, AI 25868, U01AI027659)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords
medication adherence, antiretroviral therapy, HIV infection, antiretroviral-naive patients, self-efficacy, medication non-adherence, reasons for non-adherence, depression, stress, symptom distress, social support, health perception, treatment adherence interventions
MeSH terms
Acquired Immunodeficiency Syndrome, Adolescent, Adult, Age Factors, Attitude to Health, Cross-Sectional Studies, Female, Health Status, Humans, Male, Middle Aged, Patient Compliance, Social Support, Stress, Psychological, Self Efficacy, Anti-Retroviral Agents

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