CoChat
Sign Up
Cited by 119Cardiac Ischemia and ReperfusionPhytochemicals and Medicinal PlantsCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Cardioprotection from ischemia and reperfusion injury by Withania somnifera: A hemodynamic, biochemical and histopathological assessment

Mohanty, Ipseeta, Gupta, Suresh Kumar, Talwar, Keval Krishan, Dinda, Amit, Joshi, Sujata, Bansal, Pankaj, Saxena, Amit, Arya, Dharamvir Singh·2004·Molecular and Cellular Biochemistry
DOI 10.1023/b:mcbi.0000026051.16803.03
Open this paper in CoChat — free account

Abstract

The efficacy of Withania somnifera (Ws) to limit myocardial injury after ischemia and reperfusion was explored and compared to that of Vit E, a reference standard known to reduce mortality and infarct size due to myocardial infarction. Wistar rats (150-200 g) were divided into six groups and received orally saline (sham, control group), Ws-50/kg (Ws control and treated group) and Vit E-100 mg/kg (Vit E control and treated group) respectively for 1 month. On the 31st day, rats of the control, Vit E and Ws treated groups were anesthetized and subjected to 45 min occlusion of the LAD coronary artery followed by 60 min reperfusion. Hemodynamic parameters: systolic, diastolic and mean arterial pressure (SAP, DAP, MAP), heart rate (HR), left ventricular end diastolic pressure (LVEDP), left ventricular peak (+)LVdP/dt and (-)LVdP/dt were monitored. Hearts were removed and processed for histopathological and biochemical studies: Myocardial enzyme viz, creatin phosphokinase (CPK), and antioxidant parameters: malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) were estimated. Postischemic reperfusion produced significant cardiac necrosis, depression of left ventricular functions (MAP, LVEDP, (+) and (-)LVdP/dt) and a significant fall in GSH (p < 0.01), SOD, CAT (p < 0.05), LDH and CPK (p < 0.01) as well as an increase in MDA level (p < 0.05) in the control group rats as compared to sham group. The changes in levels of protein and GPx was however, not significant. Ws and Vit E favorably modulated most of the hemodynamic, biochemical and histopathological parameters though no significant restoration in GSH, MAP (with Vit E) were observed. Ws on chronic administration markedly augmented antioxidants (GSH, GSHPx, SOD, CAT) while Vit E did not stimulate the synthesis of endogenous antioxidants compared to sham. Results indicate that Ws significantly reduced myocardial injury and emphasize the beneficial action of Ws as a cardioprotective agent.

Overview

Integrity signals

Registry

Crossref · 10.1023/b:mcbi.0000026051.16803.03

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

1 retracted

Show all 24 references

Research works printed but not linked: 3

  1. Malhotra CL, Prasad KS, Das PK, Dhalla NS: Studies on Withania somnifera (Part III). The effect of total alkaloid (Ashwagandholine) on CVS and respiration. Ind J Med Res 49: 449, 1961
  2. Aebi H: Catalase. In: H.E. Bergmayer (ed). Methods of Enzymatic Analysis, Ed. II, Vol. 2. Academic Press, New York, 1974
  3. Lamprecht W, Stan F, Weisser H, Heinz F: Determination of creatine phosphate and adenosine triphosphate with creatine kinase. In: H.U. Bergmeyer (ed). Methods of Enzymatic Analysis. Academic Press, New York, 1974, pp 1776-1778

Cited by

Sorted by citations

Items 101–119 of 119

Related

See all

Metadata

Authors
Mohanty, I., Gupta, S. K., Talwar, K. K., Dinda, A., Joshi, S., Bansal, P., Saxena, A., & Arya, D. S.
Affiliations
All India Institute of Medical Sciences (IN)
Corresponding author
Gupta, Suresh Kumar
ORCID
Venue
Molecular and Cellular Biochemistry
Publisher
Springer Science and Business Media LLC
Published
2004-05
Volume
260
Issue
1
Pages
39-47
ISSN
  • 0300-8177 (ISSN-L)
  • 1573-4919
DOI
10.1023/b:mcbi.0000026051.16803.03
OpenAlex
W2009549718
Cited by
119
References
24
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 11
FWCI
2.47
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular and Cellular Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Indian National Science Academy
  • Ministry of Environment
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
Withania somnifera, myocardial ischemia-reperfusion injury, cardioprotection, vitamin E, antioxidant enzymes, oxidative stress, malondialdehyde, glutathione, superoxide dismutase, catalase, glutathione peroxidase, creatine kinase, left ventricular function, myocardial infarction, coronary artery occlusion
MeSH terms
Animals, Blood Pressure, Catalase, Creatine Kinase, Female, Glutathione, Glutathione Peroxidase, Heart Rate, Isoproterenol, Male, Malondialdehyde, Phytotherapy, Myocardial Infarction, Myocardium, Necrosis, Plant Extracts, Superoxide Dismutase, Vitamin E, Reperfusion Injury, Myocardial Ischemia, Rats, Wistar, Ventricular Pressure, Plant Roots, Withania, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review