The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gene/environment causes of cleft lip and/or palate
Abstract
Craniofacial anomalies, and in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact. A wide range of studies in developmental biology has contributed to a better knowledge of how both genes and environmental exposures impact head organogenesis. Specific causes have now been identified for some forms of cleft lip and palate, and we are at the beginning of a time in which the common nonsyndromic forms may also have specific etiologies identified. Mouse models have an especially important role in disclosing cleft etiologies and providing models for environmental cotriggers or interventions. An overview of the gene–environment contributions to nonsyndromic forms of clefting and their implications for developmental biology and clinical counseling is presented.
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Lammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., Curry, C. J., Fernhoff, P. M., Grix, A. W., Lott, I. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510033131401 · Cited by 1,942
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
Cited by
Wehby, G., & Cassell, C. (2010) · Oral Diseases · doi:10.1111/j.1601-0825.2009.01588.x · Cited by 441
Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate
Jezewski, P. A., Vieira, A. R., Nishimura, C., Ludwig, B., Johnson, M., O’Brien, S. E., Daack-Hirsch, S., Schultz, R. E., Weber, A., Nepomucena, B., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.6.399 · Cited by 304
Self-citationEngelking, L. J., Evers, B. M., Richardson, J. A., Goldstein, J. L., Brown, M. S., & Liang, G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28988 · Cited by 82
Gunnerbeck, A., Edstedt Bonamy, A.-K., Wikström, A.-K., Granath, F., Wickström, R., & Cnattingius, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084715 · Cited by 58
“ORs were adjusted for variables that in previous studies were associated with the exposure and/or the outcome [23,24].”
MethodThe ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development
Hoffmeister, M., Prelle, C., Küchler, P., Kovacevic, I., Moser, M., Müller-Esterl, W., & Oess, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116150 · Cited by 21
Metadata
- Authors
- Murray, J.
- Venue
- Clinical Genetics
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 61
- Issue
- 4
- Pages
- 248-256
- ISSN
- 0009-9163 (ISSN-L)
- 1399-0004
- OpenAlex
- W1889850148
- Cited by
- 786
- References
- 2
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Murray, J. (2002). Gene/environment causes of cleft lip and/or palate. Clinical Genetics. https://doi.org/10.1034/j.1399-0004.2002.610402.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
