Antimicrobial effect of acidified nitrite on periodontal bacteria
Open accessAbstract
The antimicrobial agent nitric oxide (NO) is formed in the mouth and its concentration is directly related to salivary nitrite, which in turn is related to dietary nitrate intake. The aim of this study was to determine whether nitrite under acidic conditions will have an inhibitory effect, possibly occurring through NO production, on the periodontal disease pathogens Fusobacterium nucleatum, Eikenella corrodens and Porphyromonas gingivalis. Whereas the growth of these organisms was inhibited by a more acid pH, the addition of nitrite caused a marked, further dose-dependent reduction in bacterial numbers after exposure. The ability of these bacteria to recover from nitrite exposure was also affected by pH and nitrite concentration. At acidity levels below pH 5.0, low concentrations of nitrite (0.2 mM) caused effective complete killing of the periodontal bacteria. Addition of sodium thiocyanate did not increase the bacteriostatic or bacteriocidal activity of acidified nitrite against any of the 3 bacteria. These results demonstrate the possibility that nitrite in saliva, under appropriate conditions, may have an effect on the growth and survival of the bacteria implicated in periodontal disease.
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Acidified nitrite exhibits bactericidal action against several pathogens in other tissue compartments including the skin, dental caries, and gastric mucosa.
“Acidified nitrite also exhibits bactericidal action against several pathogens in other tissue compartments including the skin, dental caries, and gastric mucosa [201–206].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [204]
Acidified nitrite exhibits bactericidal action against several pathogens in other tissue compartments including the skin, dental caries, and gastric mucosa.
“Acidified nitrite also exhibits bactericidal action against several pathogens in other tissue compartments including the skin, dental caries, and gastric mucosa [201–206].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [203]
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References 14 · Cited by 100
- Authors
- Allaker, R. P., Silva Mendez, L. S., Hardie, J. M., & Benjamin, N.
- Corresponding author
- Allaker, R. P.
- ORCID
- Allaker, R. P.
- Venue
- Oral Microbiology and Immunology
- Publisher
- Wiley
- Published
- 2001-08
- Volume
- 16
- Issue
- 4
- Pages
- 253-256
- ISSN
- 0902-0055 (ISSN-L)
- 1399-302X
- OpenAlex
- W1973354480
- Cited by
- 100
- References
- 14
- Citations by year
- 2025: 7 · 2024: 10 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Oral Microbiology and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- nitric oxide, periodontal pathogens, Fusobacterium nucleatum, Eikenella corrodens, Porphyromonas gingivalis, periodontal disease, bacterial growth inhibition, pH, salivary nitrite, dietary nitrate, sodium thiocyanate, bacterial recovery
- MeSH terms
- Acids, Anti-Infective Agents, Local, Dose-Response Relationship, Drug, Humans, Hydrogen-Ion Concentration, Nitric Oxide, Nitrites, Periodontal Diseases, Saliva, Thiocyanates, Eikenella corrodens, Porphyromonas gingivalis, Fusobacterium nucleatum
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