The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Sertraline treatment of panic disorder: results of a long-term study
Abstract
Objective: To investigate the long‐term efficacy, prevention of relapse and safety of sertraline in the treatment of panic disorder. Method: This study consisted of 52 weeks of open‐label sertraline treatment (n=398) followed by a 28 weeks of a double‐blind, placebo‐controlled discontinuation trial (n=183). Results: Ninety‐three patients were randomized to sertraline and 90 were randomized to placebo. Discontinuation due to insufficient clinical response occurred in 23.6% of placebo‐treated patients and 12.0% of sertraline‐treated patients (log‐rank test, P=0.040). Thirty‐three per cent of placebo‐treated patients had an exacerbation of panic symptomatology, versus 13% of sertraline‐treated patients (log‐rank test, P=0.005). Abrupt cessation of sertraline resulted in dizziness (4.3% sertraline vs. 16.9% placebo; P=0.007) and insomnia (4.3% sertraline vs. 15.7% placebo; P=0.013) occurring at significantly higher rates. Conclusion: Long‐term sertraline treatment was effective in preventing relapse of panic disorder, well tolerated and associated with minimal discontinuation symptoms.
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In the citing paper
“Twelve studies included antidepressants for depressive disorder, and one study included antidepressants for panic disorder with or without agoraphobia (Rapaport 2001).”
From Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults (2021) · cites this paper as Rapaport 2001
In the citing paper
“Study authors reported no difference in depression between the discontinuation group (9/89; 10.1%) and the continuation group (9/92; 9.8%) (P = 1) (Rapaport 2001).”
From Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults (2021) · cites this paper as Rapaport 2001
In the citing paper
“All studies measured relapse of depression except one, which reported relapse of panic disorder in participants with panic disorder (Rapaport 2001).”
From Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults (2021) · cites this paper as Rapaport 2001
In the citing paper
“Mean change from baseline to 28 weeks on the HAM-A Scale for participants with panic disorder was 3.95 (SD 7.35) in the discontinuation group (n = 89) and 1.65 (SD 7.01) in the antidepressant group (n = 92).Study authors reported no differences between groups (P = 0.154; P value obtained from (ANCOVA) model, with treatment, site, and baseline values as effects).”
From Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults (2021) · cites this paper as Rapaport 2001
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Cited by
Bandelow, B., Zohar, J., Hollander, E., Kasper, S., Möller, H.-J., WFSBP TASK FORCE ON TREATMENT GUIDE, Bandelow, B., Zohar, J., Hollander, E., Kasper, S., et al. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970802465807 · Cited by 854
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Batelaan, N. M., Bosman, R. C., Muntingh, A., Scholten, W. D., Huijbregts, K. M., & van Balkom, A. J. L. M. (2017) · BMJ · doi:10.1136/bmj.j3927 · Cited by 153
Metadata
- Authors
- Rapaport, M. H., Wolkow, R., Rubin, A., Hackett, E., Pollack, M., & Ota, K. Y.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Rapaport, Mark Hyman
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2001-10
- Volume
- 104
- Issue
- 4
- Pages
- 289-298
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2093819587
- Semantic Scholar
- da024c2e90f2c72ed2b10174884d023c9386e27f
- Cited by
- 79
- References
- 39
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- sertraline, panic disorder, long-term treatment, relapse prevention, drug discontinuation, adverse effects, dizziness, insomnia, selective serotonin reuptake inhibitors
- MeSH terms
- Adult, Agoraphobia, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Humans, Long-Term Care, Male, Middle Aged, Recurrence, Substance Withdrawal Syndrome, Panic Disorder, Treatment Outcome, Sertraline
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- CoChat. (2026). Citation check: Sertraline treatment of panic disorder: results of a long-term study. https://app.cochat.ai/papers/10.1111/j.1600-0447.2001.00263.x
- The paper
- Rapaport, M. H., Wolkow, R., Rubin, A., Hackett, E., Pollack, M., & Ota, K. Y. (2001). Sertraline treatment of panic disorder: results of a long-term study. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/j.1600-0447.2001.00263.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
