The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Lower suicide risk with long‐term lithium treatment in major affective illness: a meta‐analysis
Abstract
Objective: To compare suicide rates with vs. without long‐term lithium treatment in major affective disorders. Method: Broad searching yielded 22 studies providing suicide rates during lithium maintenance; 13 also provide rates without such treatment. Study quality was scored, between‐study variance tested, and suicide rates on vs. off lithium examined by meta‐analyses using random‐effects regression methods to model risk ratios. Results: Among 5647 patients (33 473 patient‐years of risk) in 22 studies, suicide was 82% less frequent during lithium‐treatment (0.159 vs. 0.875 deaths/100 patient‐years). The computed risk‐ratio in studies with rates on/off lithium was 8.85 (95% CI, 4.12–19.1; P<0.0001). Higher rates off‐lithium were not accounted for by treatment‐discontinuation. Conclusion: Suicide risk was consistently lower during long‐term treatment of major affective illnesses with lithium in all studies in the meta‐analysis, including the few involving treatment‐randomization.
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Cites
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Clinical risk following abrupt and gradual withdrawal of maintenance neuroleptic treatment
Viguera, A. C. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830130055011 · Cited by 246
Outcome After Rapid vs Gradual Discontinuation of Lithium Treatment in Bipolar Disorders
Faedda, G. L. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820180046005 · Cited by 239
Flupenthixol decanoate in recurrent manic‐depressive illness: A COMPARISON WITH LITHIUM
Ahlfors, U. G., Baastrup, P. C., Dencker, S. J., Elgen, K., Lingjærde, O., Pedersen, V., Schou, M., & Aaskoven, O. (1981) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1981.tb00778.x · Cited by 155
Cited by
Goodwin, G., Haddad, P., Ferrier, I., Aronson, J., Barnes, T., Cipriani, A., Coghill, D., Fazel, S., Geddes, Jr., Grunze, H., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116636545 · Cited by 1,309
Pignone, M. P., Gaynes, B. N., Rushton, J. L., Burchell, C. M., Orleans, C. T., Mulrow, C. D., & Lohr, K. N. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-10-200205210-00013 · Cited by 1,086
Decreased risk of suicides and attempts during long‐term lithium treatment: a meta‐analytic review
Baldessarini, R. J., Tondo, L., Davis, P., Pompili, M., Goodwin, F. K., & Hennen, J. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00344.x · Cited by 753
Self-citationGeddes, J. R., Burgess, S., Hawton, K., Jamison, K., & Goodwin, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.217 · Cited by 661
Bauer, M., Bschor, T., Pfennig, A., Whybrow, P. C., Angst, J., Versiani, M., Möller, H.-J., WFSBP Task Force on Unipolar Depres, Bauer, M., Bschor, T., et al. (2007) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701227829 · Cited by 477
Metadata
- Authors
- Tondo, L., Hennen, J., & Baldessarini, R. J.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2001-09
- Volume
- 104
- Issue
- 3
- Pages
- 163-172
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2100911776
- Cited by
- 269
- References
- 5
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tondo, L., Hennen, J., & Baldessarini, R. J. (2001). Lower suicide risk with long‐term lithium treatment in major affective illness: a meta‐analysis. Acta Psychiatrica Scandinavica. https://doi.org/10.1034/j.1600-0447.2001.00464.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
