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Soluble membrane‐type 1 matrix metalloproteinase (MT1‐MMP) and gelatinase A (MMP‐2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis

MAISI, PÄIVI, PRIKK, KAIU, SEPPER, RUTH, PIRILÄ, EMMA, SALO, TUULA, HIETANEN, JARKKO, SORSA, TIMO·2002·APMIS
DOI 10.1034/j.1600-0463.2002.1101102.x
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Abstract

The aim of this study was to investigate the involvement of the MT1‐MMP/MMP‐2 cascade in induced sputum (IS) and bronchoalveolar lavage fluid (BALF) from bronchial asthma (BA) and bronchiectasis (BE) patients and healthy controls. The molecular forms and cellular origins of MT1‐MMP and MMP‐2 were determined by Western immunoblotting, immunohistochemistry and in situ hybridization. Elevated levels of soluble activated and autocatalyzed MT1‐MMP species as well as activated forms of MMP‐2 in IS and BALF samples from BA and BE patients were evidenced. The activation degrees of soluble MT1‐MMP and MMP‐2 were significantly correlated in BA and BE IS and BALF. Only low levels of both these MMPs were observed in healthy control IS and BALF. The co‐expression of MMP‐2 with MT1‐MMP was evidenced by double immunostaining in bronchial epithelial cells, submucosal glandular cells, smooth muscle cells and monocyte/macrophages. The MT1‐MMP/MMP‐2 cascade is present and active in human inflammatory lung disease fluid and tissue samples. This cascade seemingly reflects the active destructive phases of these chronic lung diseases.

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Crossref · 10.1034/j.1600-0463.2002.1101102.x

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  • MT1-MMP is constitutively shed via proteolytic cleavage by ADAM family metalloproteinases, resulting in detectable quantities of soluble MT1-MMP (sMT1-MMP) in the plasma.

    “MT1-MMP is constitutively shed via proteolytic cleavage by A Disintegrin and Metalloproteinase (ADAM) family metalloproteinases, resulting in detectable quantities of soluble MT1-MMP (sMT1-MMP) in the plasma20–22.”

    From MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity (2025) · cites this paper as [21]

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Metadata

Authors
MAISI, P., PRIKK, K., SEPPER, R., PIRILÄ, E., SALO, T., HIETANEN, J., & SORSA, T.
Venue
APMIS
Publisher
Wiley
Published
2002-11
Volume
110
Issue
11
Pages
771-782
ISSN
  • 0903-4641
  • 1600-0463
DOI
10.1034/j.1600-0463.2002.1101102.x
Cited by
52
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 105 d)

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