Langerhans cell migration is modulated by N-sulfated glucosamine moieties in heparin
Abstract
Abstract: Dendritic cell (DC) migration into and out of tissues is important for the generation of primary immune responses to antigens encountered in tissues. In order to study the mechanisms involved in DC migration we used a skin explant system and quantitated the number of Langerhans cells (LC), which are immature precursors of DC in skin‐draining lymph nodes, remaining in the epidermis in response to incubation with various biomolecules. This paper shows that LC trafficking in epidermis is a metabolically active process that is modulated by heparin, specifically by N‐sulfated glucosamine moieties in heparin. This is the first demonstration of structural specificity in the biochemical requirements for DC migration in a tissue and therefore is important to understanding DC migration in general.
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Activation of the innate immune system by polysaccharides leads to attraction of macrophages and natural killer cells to the target site and production of tumoricidal cytokines.
“The main mechanism of action of polysaccharides cytotoxic effect is the activation of the innate immune system [165,166,167,168], leading to attraction of macrophages and natural killer cells to the target site and production of tumoricidal cytokines [166,169,170,171].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [171]
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Cited by 13
- Authors
- O'Sullivan, G. M., Boswell, C. M., & Halliday, G. M.
- Affiliations
- The University of Sydney (AU)
- ORCID
- Halliday, G. M.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2000-02
- Volume
- 9
- Issue
- 1
- Pages
- 25-33
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2042586344
- Cited by
- 13
- References
- 0
- Citations by year
- 2024: 1 · 2019: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Sydney
- Johnson and Johnson
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Keywords
- Langerhans cells, dendritic cell migration, heparin, epidermis, skin-draining lymph nodes, skin explants, cell trafficking, glycosaminoglycans, immune response
- MeSH terms
- Animals, Carbohydrate Sequence, Cell Movement, Electron Transport Complex IV, Female, Glucosamine, Heparin, Langerhans Cells, Mice, Inbred BALB C, Molecular Sequence Data, Proteoglycans, Mice, In Vitro Techniques
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