The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Abstract
OBJECTIVE: To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. DESIGN: Training of evaluators, application, and assessment over 2 consecutive days. SETTING: An academic center. PATIENTS: Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients > or = 8 years) and cohort 2 (10 patients < 8 years). INTERVENTIONS: None. MAIN OUTCOME MEASURE: The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. RESULTS: Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. CONCLUSIONS: This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.
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“Severity scoring systems are routinely used to assist clinicians with treatment decisions and to evaluate treatment efficacy in practice.8”
From Assessing the performance of artificial intelligence models in evaluating inflammatory skin disease severity: a systematic review and meta-analysis (2025) · cites this paper as [8]
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Cites
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Self-citationA 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients
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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110
Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis
Beck, L. A., Thaçi, D., Hamilton, J. D., Graham, N. M. H., Bieber, T. R. M., Rocklin, R. E., Ming, J. E., Ren, H., Kao, R., Simpson, E. L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314768 · Cited by 1,435
Guidelines of care for the management of atopic dermatitis
Eichenfield, L. F., Tom, W. L., Chamlin, S. L., Feldman, S. R., Hanifin, J. M., Simpson, E. L., Berger, T. G., Bergman, J. N., Cohen, D. E., Cooper, K. D., et al. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.10.010 · Cited by 1,305
Self-citationEpidemiology of atopic dermatitis in adults: Results from an international survey
Barbarot, S., Auzière, S., Gadkari, A., Girolomoni, G., Puig, L., Simpson, E. L., Margolis, D. J., de Bruin-Weller, M. S., & Eckert, L. (2018) · Allergy · doi:10.1111/all.13401 · Cited by 890
Targeting key proximal drivers of type 2 inflammation in disease
Gandhi, N. A., Bennett, B. L., Graham, N. M. H., Pirozzi, G., Stahl, N., & Yancopoulos, G. D. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd4624 · Cited by 766
Metadata
- Authors
- Hanifin, J. M., Thurston, M., Omoto, M., Cherill, R., Tofte, S. J., Graeber, M., & Evaluator Group, T. E.
- Affiliations
- Oregon Health & Science University (US)
- Novartis (Switzerland) (CH)
- Shiga University of Medical Science (JP)
- Corresponding author
- Hanifin, J. M.
- ORCID
- Hanifin, J. M.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2001-02
- Volume
- 10
- Issue
- 1
- Pages
- 11-18
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2117359358
- Cited by
- 1,200
- References
- 17
- Citations by year
- 2026: 69 · 2025: 85 · 2024: 92 · 2023: 101 · 2022: 84 · 2021: 98 · 2020: 82 · 2019: 63 · 2018: 47 · 2017: 46 · 2016: 53 · 2015: 28 · 2014: 43 · 2013: 23 · 2012: 21
- FWCI
- 20.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- Eczema Area and Severity Index, atopic dermatitis, inter-rater reliability, intra-rater reliability, disease severity assessment, disease extent assessment, clinical trial outcome measures
- MeSH terms
- Adolescent, Adult, Child, Child, Preschool, Dermatitis, Atopic, Dermatology, Eczema, Humans, Infant, Infant, Newborn, Severity of Illness Index, Reproducibility of Results, Cohort Studies, Observer Variation
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