A stochastic view of lymphocyte motility and trafficking within the lymph node
Abstract
Two-photon microscopy is providing literal insight into the cellular dynamics of lymphoid organs and, guided by analysis of three-dimensional images, into mechanisms that underlie cell migration and antigen recognition in vivo. This review describes lymphocyte motility and antigen recognition in the native tissue environment and compares these results with a much more extensive literature on lymphocyte motility, signaling, and chemotaxis in vitro. We discuss the in vitro literature on dynamic aspects of lymphocyte motility, chemotaxis, and the response to antigen and present the view that random migration of lymphocytes may drive a stochastic mechanism of antigen recognition in lymphoid organs, rather than being guided by chemotaxis.
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TREM2 recognizes myelin-associated lipids.
“It was previously demonstrated that TREM2 recognizes myelin-associated lipids [42, 52], suggesting that TREM2 may directly sense lipid components exposed after myelin damage.”
From TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis (2020) · cites this paper as [52]
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- Authors
- Wei, S. H., Parker, I., Miller, M. J., & Cahalan, M. D.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Cahalan, Michael D.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2003-09-10
- Volume
- 195
- Issue
- 1
- Pages
- 136-159
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2136695636
- Cited by
- 117
- References
- 180
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 3
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- lymphocyte motility, lymphocyte migration, lymph nodes, antigen recognition, chemotaxis, random migration, stochastic mechanisms, cell migration, lymphoid organs
- MeSH terms
- Animals, Chemotaxis, Humans, Lymph Nodes, Lymphocytes, Antigen Presentation, Chemokines, Calcium Signaling
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