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Desensitization and Subsequent Kidney Transplantation of Patients Using Intravenous Immunoglobulins (IVIg)
Open accessAbstract
Transplantation of patients possessing antibodies against allo-HLA antigens can be delayed for years. We have shown that administration of intravenous immunoglobulins (IVIg) can induce a profound and sustained decrease in the titers of anti-HLA antibodies. We report here the first series of patients desensitized, then transplanted using IVIg therapy. Fifteen patients have been included and treated with IVIg, given as 3 monthly courses of 2g/kg body weight. Thirteen of those 15 patients (87%) were effectively desensitized and underwent immediate transplantation. Eleven were transplanted with a cadaveric donor, and two with a living donor against which the pretreatment cross-match was positive. One graft was lost from thrombosis and one from rejection. All other patients had uneventful courses, without any episodes of rejection, with a follow-up of more than 1 year. Thus, IVIg therapy allows safe and prompt kidney transplantation of immunized patients.
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Cited by
Jordan, S. C., Tyan, D., Stablein, D., McIntosh, M., Rose, S., Vo, A., Toyoda, M., Davis, C., Shapiro, R., Adey, D., et al. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000145878.92906.9f · Cited by 435
Lorant, T., Bengtsson, M., Eich, T., Eriksson, B.-M., Winstedt, L., Järnum, S., Stenberg, Y., Robertson, A.-K., Mosén, K., Björck, L., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14733 · Cited by 108
Metadata
- Authors
- Glotz, D., Antoine, C., Julia, P., Suberbielle‐Boissel, C., Boudjeltia, S., Fraoui, R., Hacen, C., Duboust, A., & Bariety, J.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 2
- Issue
- 8
- Pages
- 758-760
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2007350320
- Cited by
- 269
- References
- 0
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Desensitization and Subsequent Kidney Transplantation of Patients Using Intravenous Immunoglobulins (IVIg). https://app.cochat.ai/papers/10.1034/j.1600-6143.2002.20809.x
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- Glotz, D., Antoine, C., Julia, P., Suberbielle‐Boissel, C., Boudjeltia, S., Fraoui, R., Hacen, C., Duboust, A., & Bariety, J. (2002). Desensitization and Subsequent Kidney Transplantation of Patients Using Intravenous Immunoglobulins (IVIg). American Journal of Transplantation. https://doi.org/10.1034/j.1600-6143.2002.20809.x
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