The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Campath-1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study
Open accessAbstract
Campath-1H, an anti-CD52 monoclonal antibody, was used as induction therapy (40 mg i.v. total dose) in 29 primary human renal transplants, and the patients were maintained on rapamycin monotherapy (levels 8-15 ng/mL) post-transplant. Campath-1H profoundly depletes lymphocytes long-term and more transiently depletes B cells and monocytes. All patients are alive and well at 3-29 months of follow up. One graft was lost because of rejection. There have been no systemic infections and no malignancies. Eight of 29 patients have experienced rejection, which was successfully treated in seven of eight patients. Five of these patients had pathological evidence of a humoral component of their rejection. Seven of the 29 patients were converted to standard triple therapy on account of rejection. Rapamycin was generally well tolerated in that there were no significant wound-healing problems; two lymphoceles required surgical drainage; and most patients were treated with a lipid-lowering agent. Flow crossmatch testing post-transplant revealed evidence of alloantibody in two patients tested with previous combined cellular and humoral rejection. Biopsies have shown no chronic allograft nephropathy to date. In view of the relatively high incidence of early humoral rejection, we plan to modify the immunosuppressive regimen in subsequent pilot studies. This clinical trial provides insight into the use of Campath-1H induction in combination with rapamycin maintenance monotherapy.
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COLLINS, A. B., SCHNEEBERGER, E. E., PASCUAL, M. A., SAIDMAN, S. L., WILLIAMS, W. W., TOLKOFF-RUBIN, N., COSIMI, A. B., & COLVIN, R. B. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v10102208 · Cited by 515
Self-citationMauiyyedi, S., Crespo, M., Collins, A. B., Schneeberger, E. E., Pascual, M. A., Saidman, S. L., Tolkoff-Rubin, N. E., Williams, W. W., Delmonico, F. L., Cosimi, A. B., et al. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v133779 · Cited by 492
Self-citationCalne, R., Friend, P., Moffatt, S., Bradley, A., Hale, G., Firth, J., Bradley, J., Smith, K., & Waldmann, H. (1998) · The Lancet · doi:10.1016/s0140-6736(05)77739-4 · Cited by 435
Spitzer, T. R., Delmonico, F., Tolkoff-Rubin, N., McAfee, S., Sackstein, R., Saidman, S., Colby, C., Sykes, M., Sachs, D. H., & Cosimi, A. B. (1999) · Transplantation · doi:10.1097/00007890-199908270-00006 · Cited by 419
Crespo, M., Pascual, M., Tolkoff-Rubin, N., Mauiyyedi, S., Bernard Collins, A., Fitzpatrick, D., Lin Farrell, M., Williams, W. W., Delmonico, F. L., Benedict Cosimi, A., et al. (2001) · Transplantation · doi:10.1097/00007890-200103150-00013 · Cited by 351
Self-citationCAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTS
Calne, R., Moffatt, S. D., Friend, P. J., Jamieson, N. V., Bradley, J. A., Hale, G., Firth, J., Bradley, J. R., Smith, K. G. C., & Waldmann, H. (1999) · Transplantation · doi:10.1097/00007890-199911270-00032 · Cited by 305
T Cell Death and Transplantation Tolerance
Li, X. C., Strom, T. B., Turka, L. A., & Wells, A. D. (2001) · Immunity · doi:10.1016/s1074-7613(01)00121-2 · Cited by 207
LeGrand, A., Fermor, B., Fink, C., Pisetsky, D. S., Weinberg, J. B., Vail, T. P., & Guilak, F. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200109)44:9<1998::aid-art348>3.0.co;2-t · Cited by 204
THE FLOW CYTOMETRIC CROSSMATCH
Bray, R. A., Lebeck, L. K., & Gebel, H. M. (1989) · Transplantation · doi:10.1097/00007890-198911000-00022 · Cited by 124
Self-citationIkonen, T. S., Gummert, J. F., Hayase, M., Honda, Y., Hausen, B., Christians, U., Berry, G. J., Yock, P. G., & Morris, R. E. (2000) · Transplantation · doi:10.1097/00007890-200009270-00015 · Cited by 110
Cited by
Transplantation 50 Years Later — Progress, Challenges, and Promises
Sayegh, M. H., & Carpenter, C. B. (2004) · New England Journal of Medicine · doi:10.1056/nejmon043418 · Cited by 425
Steroid avoidance or withdrawal for kidney transplant recipients
Haller, M. C., Royuela, A., Nagler, E. V., Pascual, J., & Webster, A. C. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005632.pub3 · Cited by 258
A comprehensive review of immunosuppression used for liver transplantation
Mukherjee, S., & Mukherjee, U. (2009) · Journal of Transplantation · doi:10.1155/2009/701464 · Cited by 140
Viklicky, O., Hruba, P., Tomiuk, S., Schmitz, S., Gerstmayer, B., Sawitzki, B., Miqueu, P., Mrazova, P., Tycova, I., Svobodova, E., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0169624 · Cited by 12
Metadata
- Authors
- Knechtle, S. J., Pirsch, J. D., Fechner, J. H., Becker, B. N., Friedl, A., Colvin, R. B., Lebeck, L. K., Chin, L. T., Becker, Y. T., Odorico, J. S., D’Alessandro, A. M., Kalayoglu, M., Hamawy, M. M., Hu, H., Bloom, D. D., & Sollinger, H. W.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 3
- Issue
- 6
- Pages
- 722-730
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2081695157
- Cited by
- 379
- References
- 11
- FWCI
- 22.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Campath-1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study. https://app.cochat.ai/papers/10.1034/j.1600-6143.2003.00120.x
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- Knechtle, S. J., Pirsch, J. D., Fechner, J. H., Becker, B. N., Friedl, A., Colvin, R. B., Lebeck, L. K., Chin, L. T., Becker, Y. T., Odorico, J. S., D’Alessandro, A. M., Kalayoglu, M., Hamawy, M. M., Hu, H., Bloom, D. D., & Sollinger, H. W. (2003). Campath-1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study. American Journal of Transplantation. https://doi.org/10.1034/j.1600-6143.2003.00120.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
