Genetic testing: Psychological aspects and implications.

Abstract

As the number of genes associated with inherited disease continues to grow, researchers and practitioners in behavioral medicine will encounter complex psychological issues faced by individuals at risk for these diseases. A review of the literature concerning prenatal, carrier, and predictive genetic testing suggests that the severity of psychological risks posed by research-based genetic testing is not great. However, subgroups of individuals with particular psychological traits may be more vulnerable to adverse effects. Available data do not provide evidence that genetic testing promotes changes in health-related behaviors. Thus, although there may be less of a role for mental health professionals in the psychological counseling of genetic testing participants, there is a need for research and practice to facilitate health protective behaviors in response to genetic risk information.

Cites (94)

1. A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
   Miki, Yoshio, Swensen, Jeff, Shattuck-Eidens, Donna, Futreal, P. Andrew, Harshman, Keith, Tavtigian, Sean, Liu, Qingyun, Cochran, Charles, Bennett, L. Michelle, Ding, Wei et al. · 1994 · Science
2. Decision making: A psychological analysis of conflict, choice, and commitment
   1978 · Evaluation and Program Planning
3. Projecting Individualized Probabilities of Developing Breast Cancer for White Females Who Are Being Examined Annually
   Gail, M. H., Brinton, L. A., Byar, D. P., Corle, D. K., Green, S. B., Schairer, C., Mulvihill, J. J. · 1989 · JNCI Journal of the National Cancer Institute
4. The Risk of Cancer Associated with Specific Mutations of BRCA1 and BRCA2 among Ashkenazi Jews
   Struewing, Jeffery P., Hartge, Patricia, Wacholder, Sholom, Baker, Sonya M., Berlin, Martha, McAdams, Mary, Timmerman, Michelle M., Brody, Lawrence C., Tucker, Margaret A. · 1997 · New England Journal of Medicine
5. Risks of cancer in BRCA1-mutation carriers
   FORD, D · 1994 · The Lancet
6. Birth Defects: Original Article Series.
   1971 · Annals of Internal Medicine
7. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.
   Douglas F. Easton, David Timothy Bishop, Deborah Ford, Gillian P. Crockford · 1993 · Europe PMC (PubMed Central)
8. Structural analysis of social behavior.
   Benjamin, Lorna Smith · 1974 · Psychological Review
9. Guidelines for perinatal care
   Gynecologists · 1983 · Medical Entomology and Zoology
10. BRCA1 Testing in Families With Hereditary Breast-Ovarian Cancer: A Prospective Study of Patient Decision Making and Outcomes
    Lerman, Caryn · 1996 · JAMA

Show all 94 references

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   Persky, Susan, Kaphingst, Kimberly A., Condit, Celeste M., McBride, Colleen M. · 2007 · Genetics in Medicine

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