Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear.
Abstract
The effects of amygdala, hippocampus, and periaqueductal gray (PAG) lesions on contextual fear conditioning in rats were examined. Freezing behavior served as the measure of conditioning. Unlesioned control animals showed reliable conditional freezing in the testing chamber when observed both immediately and 24 hr after footshocks. In contrast, rats with amygdala or ventral PAG lesions exhibited a significant attenuation in freezing both immediately and 24 hr after the shocks. Dorsal PAG lesions had no effect on freezing at either time. Animals with hippocampal lesions displayed robust freezing behavior immediately following the shock, even though they showed a marked deficit in freezing 24 hr after the shock. These results indicate that there are anatomically dissociable short- and long-term conditional fear states.
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Lesions of the ventrolateral periaqueductal grey but not of the dorsal or dorsolateral periaqueductal grey disrupt freezing.
“Lesions of the vlPAG [14,50,51] but not of the dorsal or dorsolateral (dl) PAG [52] disrupt freezing.”
From Freeze for action: neurobiological mechanisms in animal and human freezing (2017) · cites this paper as [52]
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References 33 · Cited by 615
- Authors
- Kim, J. J., Rison, R. A., & Fanselow, M. S.
- Affiliations
- University of Southern California (US)
- University of California, Los Angeles (US)
- Venue
- Behavioral Neuroscience
- Published
- 1993
- Volume
- 107
- Issue
- 6
- Pages
- 1093-1098
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2001477070
- Cited by
- 615
- References
- 33
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 18 · 2023: 15 · 2022: 15 · 2021: 12 · 2020: 12 · 2019: 16 · 2018: 12 · 2017: 16 · 2016: 23 · 2015: 17 · 2014: 24 · 2013: 15 · 2012: 27
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh039786-09)
- National Institute of Mental Health (MH39786)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- contextual fear conditioning, amygdala lesions, hippocampal lesions, periaqueductal gray, ventral periaqueductal gray, dorsal periaqueductal gray, freezing behavior, footshock, memory consolidation
- MeSH terms
- Amygdala, Animals, Association Learning, Brain Mapping, Conditioning, Classical, Electroshock, Fear, Female, Hippocampus, Neural Pathways, Neuronal Plasticity, Periaqueductal Gray, Mental Recall, Retention, Psychology, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Rats
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