Mode-specific effects among three treatments for depression.

Abstract

In the NIMH Treatment of Depression Collaborative Research Program (TDCRP), 250 depressed outpatients were randomly assigned to interpersonal psychotherapy, cognitive-behavioral therapy, imipramine plus clinical management, or pill placebo plus clinical management treatments. Although all treatments demonstrated significant symptom reduction with few differences in general outcomes, an important question concerned possible effects specific to each treatment. The therapies differ in rationale and procedures, suggesting that mode-specific effects may differ among treatments, each of which was precisely specified, applied appropriately, and shown to be discriminable. Outcome measures were selected for presumed sensitivity to the different treatments. Findings provided only scattered and relatively insubstantial support for mode-specific differences. None of the therapies produced consistent effects on measures related to its theoretical origins.

Cites (38)

1. Statistical power analysis for the behavioral sciences
   1990 · Computers, Environment and Urban Systems
2. An inventory for measuring depression
   BECK, A. T. · 1961 · Archives of General Psychiatry
3. Cognitive Therapy for Depression: (675542012-001)
   2012 · PsycEXTRA Dataset
4. Development of a Rating Scale for Primary Depressive Illness
   HAMILTON, MAX · 1967 · British Journal of Social and Clinical Psychology
5. Simultaneous Statistical Inference
   Miller, Rupert G. · 1981 · Springer Series in Statistics
6. National Institute of Mental Health Treatment of Depression Collaborative Research Program: General Effectiveness of Treatments
   Elkin, Irene · 1989 · Archives of General Psychiatry
7. Interpersonal Psychotherapy Of Depression
   Gerald L. Klerman · 1984 · Medical Entomology and Zoology
8. Some implicit common factors in diverse methods of psychotherapy.
   Rosenzweig, Saul · 1936 · American Journal of Orthopsychiatry
9. Handbook of affective disorders
   Eugene S. Paykel · 1982 · Medical Entomology and Zoology
10. The Hopkins Symptom Checklist (HSCL)
    Lipman, Ronald S., Covi, Lino, Shapiro, Arthur K. · 1979 · Journal of Affective Disorders

Show all 38 references

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