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Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis
Abstract
This study conducted a systematic review to assess the quality of existing literature on psychological treatments for irritable bowel syndrome and to quantify the evidence for their efficacy. Three independent reviewers (2 from England, 1 from the United States) coded the quality of 32 studies, 17 of which provided data suitable for meta-analysis. Meta-analysis of efficacy data (50% reduction of symptoms) gave an odds ratio of 12 (95% confidence interval = 5.56-25.96) and a number needed to treat of 2. Psychological treatments are, as a class of interventions, effective in reducing symptoms compared with a pooled group of control conditions. Questions regarding the relative superiority of specific psychological treatments and influence of active versus nonspecific treatment effects remain unanswered.
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“The average effect on GI symptoms after treatment (d ¼ 0.69) in our analysis was similar to that reported previously for bowel dysfunction (d ¼ 0.57) and considerably higher than that reported previously for abdominal pain (d ¼ 0.27) in the only previously published meta-analysis on this topic using continuous outcomes.7”
From Short-term and long-term efficacy of psychological therapies for irritable bowel syndrome: a systematic review and meta-analysis (2016) · cites this paper as [7]
In the citing paper
“Meta-analyses suggest that psychological therapies are as effective as antidepressants in reducing GI symptoms in IBS immediately after treatment, with a number needed to treat between 2 and 4. [5][6][7]”
From Short-term and long-term efficacy of psychological therapies for irritable bowel syndrome: a systematic review and meta-analysis (2016) · cites this paper as [7]
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Assessing the Quality of Randomized Controlled Trials of Psychodynamic Psychotherapy
Gerber, A. J., Kocsis, J. H., Milrod, B. L., & Roose, S. P. (2006) · Journal of the American Psychoanalytic Association · doi:10.1177/00030651060540040103 · Cited by 5
Síndrome do intestino irritável: um exercício em análise funcional do comportamento
Bohm, C. H., & Gimenes, L. D. S. (2010) · Interação em Psicologia · doi:10.5380/psi.v14i2.15600 · Cited by 4
Melehin, A. I. (2020) · Clinical Psychology and Special Education · doi:10.17759/cpse.2020090201 · Cited by 3
Sarkar, S., Choudhury, S., Balasundaram, S., & Balasubramanian, S. (2020) · Industrial Psychiatry Journal · doi:10.4103/ipj.ipj_59_18 · Cited by 6
“[21] Psychological interventions are known to improve IBS and other GI symptoms by thereby altering this circuitry.[44,45] Following such interventions, psychological distress and QOL are also said to improve possibly due to improved bowel functioning.”
BackgroundChang, M., Shapiro, D., Karve, S. J., Shahabi, L., Tan, S., Smith, S. E., Hui, K.-K. P., Tillisch, K., Mayer, E. A., & Naliboff, B. D. (2013) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2013.0197 · Cited by 4
Should we incorporate psychological care into the management of IBS?
Palsson, O. S. (2006) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0597 · Cited by 4
Psychological Treatment of Irritable Bowel Syndrome
Quinton, S., & Keefer, L. (2014) · Wiley eBooks · doi:10.1002/9781118453940.ch22 · Cited by 1
Marks, D. F. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop209001 · Cited by 4
Lackner, J. M. (2024) · Pain · doi:10.1097/j.pain.0000000000003186 · Cited by 3
Self-citationWertheim, B., Aarts, E., de Roos, C., & van Rood, Y. R. (2023) · Trials · doi:10.1186/s13063-023-07784-1 · Cited by 3
Howard, K., Ahmad, S. S., Chavez, J. V., Hoogerwoerd, H., & McIntosh, R. C. (2024) · Scientific Reports · doi:10.1038/s41598-024-61418-3 · Cited by 3
“Nonetheless, there is parallel evidence supporting the impact of cognitive emotion regulation strategies on gastrointestinal complaints is robust 75–78 .”
BackgroundSchulz, K. P., Sysko, R., Fan, J., & Hildebrandt, T. (2025) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2024.12.013 · Cited by 4
Metadata
- Authors
- Lackner, J. M., Mesmer, C., Morley, S., Dowzer, C., & Hamilton, S.
- Affiliations
- Erie County Medical Center (US)
- University at Buffalo, State University of New York (US)
- University of Leeds (GB)
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2004
- Volume
- 72
- Issue
- 6
- Pages
- 1100-1113
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- OpenAlex
- W2043126698
- Cited by
- 295
- References
- 97
- Citations by year
- 2025: 5 · 2024: 11 · 2023: 4 · 2022: 9 · 2021: 2 · 2020: 9 · 2019: 12 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 14 · 2014: 21 · 2013: 20 · 2012: 19
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK054211, DK-54211)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- irritable bowel syndrome, psychological intervention, symptom relief, treatment efficacy, psychotherapy, number needed to treat
- MeSH terms
- Humans, Psychotherapy, Irritable Bowel Syndrome
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