Rapid response to treatment for binge eating disorder
Abstract
The authors examined rapid response among 108 patients with binge eating disorder (BED) who were randomly assigned to 1 of 4 16-week treatments: fluoxetine, placebo, cognitive-behavioral therapy (CBT) plus fluoxetine, or CBT plus placebo. Rapid response, defined as 65% or greater reduction in binge eating by the 4th treatment week, was determined by receiver operating characteristic curves. Rapid response characterized 44% of participants and was unrelated to participants' demographic or baseline characteristics. Participants with rapid response were more likely to achieve binge-eating remission, had greater improvements in eating-disorder psychopathology, and had greater weight loss than participants without rapid response. Rapid response had different prognostic significance and distinct time courses for CBT versus pharmacotherapy-only treatments. Rapid response has utility for predicting outcomes and provides evidence for specificity of treatment effects with BED.
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Rapid response to CBT is associated with long-term improvements in functioning and a reduction in long-term relapse rates.
“Furthermore, this rapid response is associated with long-term improvements in functioning and a reduction in long-term relapse rates [39,43,45].”
Similar rapid gains are observed in CBT for post-traumatic stress disorder, adolescent depression, binge eating, and irritable bowel syndrome.
“Similar gains are observed in CBT for post-traumatic stress disorder (PTSD; 53 percent of clients), adolescent depression, binge eating (62 percent of clients), and irritable bowel syndrome (30 percent of clients) [41,42,43,44].”
Improvements in openness to experience, awareness, and particularly stress and valued action are broadly congruent with the existing literature on brief interventions and improvements early in therapy.
“Improvements in openness to experience, awareness, and particularly stress and valued action are broadly congruent with the existing literature on brief interventions and improvements early in therapy.”
Sudden improvements for 40 to 60% of clients following brief interventions and initial therapy sessions are a well-observed effect in the cognitive behavioural therapies.
“For example, sudden improvements for 40 to 60% of clients following brief interventions and initial therapy sessions are a well-observed effect in the cognitive behavioural therapies [41,42,43,44].”
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References 56 · Cited by 117
- Authors
- Grilo, C. M., Masheb, R. M., & Wilson, G. T.
- Affiliations
- Yale University (US)
- Rutgers, The State University of New Jersey (US)
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2006
- Volume
- 74
- Issue
- 3
- Pages
- 602-613
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- OpenAlex
- W2010221507
- Cited by
- 117
- References
- 56
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 6 · 2012: 9
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R01 DK49587; K24 DK070052)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- binge eating disorder, rapid response, fluoxetine, cognitive behavioral therapy, treatment response prediction, weight loss, eating disorder psychopathology, pharmacotherapy
- MeSH terms
- Adolescent, Adult, Double-Blind Method, Female, Fluoxetine, Humans, Male, Middle Aged, Obesity, Cognitive Behavioral Therapy, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Bulimia Nervosa
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