Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.

Hippocampal acetylcholine depletion has no effect on anxiety, spatial novelty preference, or differential reward for low rates of responding (DRL) performance in rats.

McHugh, S. B., Francis, A. G., McAuley, J. D., Stewart, A. L., Baxter, M. G., & Bannerman, D. M. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000072 · Cited by 14

Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections

Fitz, N. F., Gibbs, R. B., & Johnson, D. A. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.03.011 · Cited by 14

Subtle learning and memory impairment in an idiopathic rat model of Alzheimer's disease utilizing cholinergic depletions and β-amyloid

Deibel, S. H., Weishaupt, N., Regis, A. M., Hong, N. S., Keeley, R. J., Balog, R. J., Bye, C. M., Himmler, S. M., Whitehead, S. N., & McDonald, R. J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.033 · Cited by 13

Basal forebrain damage and object-recognition in rats

Kornecook, T. J., Kippin, T. E., & Pinel, J. P. J. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00053-9 · Cited by 13

Spatial memory alterations by activation of septal 5HT1A receptors: no implication of cholinergic septohippocampal neurons

Koenig, J., Lecourtier, L., Cosquer, B., Pereira, P. M., & Cassel, J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2049-7 · Cited by 13

Cognitive effects of neurotoxic lesions of the nucleus basalis magnocellularis in rats: Differential roles for corticopetal versus amygdalopetal projections

Beninger, R. J., Dringenberg, H. C., Boegman, R. J., & Jhamandas, K. H. (2001) · Neurotoxicity Research · doi:10.1007/bf03033227 · Cited by 13

Chapter 1 Toward a Cognitive Neuroscience of Normal Aging

Rapp, P. R., & Gallagher, M. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60051-6 · Cited by 13

Effect of 192IgG-saporin injections into the nucleus basalis magnocellularis on acquisition and performance of a go/no-go procedure in the rat

Curzon, P., Bannon, A. W., & Decker, M. W. (1999) · Psychobiology · doi:10.3758/bf03332105 · Cited by 12

Nucleus basalis injections of N-methyl-D-aspartate enhance memory of rats in the double Y-maze

Mason, K. I., Mallet, P. E., Jhamandas, K. H., Boegman, R. J., & Beninger, R. J. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00146-4 · Cited by 13

Effects of Glucose on Scopolamine-Induced Learning Deficits in Rats Performing the Morris Water Maze Task

Okaichi, Y., & Okaichi, H. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3940 · Cited by 12

Pretraining or previous non-spatial experience improves spatial learning in the Morris water maze of nucleus basalis lesioned rats

Nieto-Escámez, F. A., Sánchez-Santed, F., & de Bruin, J. P. C. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00182-7 · Cited by 12

Cholinergic deafferentation of the hippocampus causes non-temporally graded retrograde amnesia in an odor discrimination task

Köppen, J. R., Stuebing, S. L., Woodbury, M., Blackwell, A. A., Blankenship, P. A., Cheatwood, J. L., & Wallace, D. G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.021 · Cited by 11

Organization of food protection behavior is differentially influenced by 192 IgG-saporin lesions of either the medial septum or the nucleus basalis magnocellularis

Martin, M. M., Winter, S. S., Cheatwood, J. L., Carter, L. A., Jones, J. L., Weathered, S. L., Wagner, S. J., & Wallace, D. G. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.018 · Cited by 11

The effects of nucleus basalis magnocellularis lesions in Long-Evans hooded rats on two learning set formation tasks, delayed matching-to-sample learning, and open-field activity.

Bailey, A. M., & Thomas, R. K. (2001) · Behavioral Neuroscience · doi:10.1037//0735-7044.115.2.328 · Cited by 17

The consequences of atheoretical, task-driven experimentation: Theoretical comment on Paban, Chambon, Jaffard, and Alescio-Lautier (2005).

Sarter, M. F. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.2.493 · Cited by 10

Cognitive dysfunctions induced by scopolamine are reduced by systemic or intrahippocampal mineralocorticoid receptor blockade.

Smythe, J. W., Murphy, D., Timothy, C., Gül, G., & Costall, B. (1997) · Pharmacology, Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00415-7 · Cited by 12

Cortical Metabolic Deficits in a Rat Model of Cholinergic Basal Forebrain Degeneration

Gelfo, F., Petrosini, L., Graziano, A., Bartolo, P. D., Burello, L., Vitale, E., Polverino, A., Iuliano, A., Sorrentino, G., & Mandolesi, L. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1120-2 · Cited by 9

Cholinergic input to the hippocampus is not required for a model of episodic memory in the rat, even with multiple consecutive events

Seel, S. V., Eacott, M. J., Langston, R. F., & Easton, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.001 · Cited by 9

Behavioral and immunohistological effects of cholinergic damage in immunolesioned rats: Alteration of c-Fos and polysialylated neural cell adhesion molecule expression

Chambon, C., Paban, V., Manrique, C., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.022 · Cited by 9

Nonhippocampal Muscarinic Receptors Are Required for Nonspatial Working Memory

Wan, R.-Q., Pang, K. C. H., & Olton, D. S. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00146-9 · Cited by 8

Impact of Chronic Stress on the Spatial Learning and GR-PKAc-NF-κB Signaling in the Hippocampus and Cortex in Rats Following Cholinergic Depletion

Lee, S., Cho, W.-H., Lee, Y.-S., & Han, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0620-5 · Cited by 7

Lesions to the nucleus basalis magnocellularis lower performance but do not block the retention of a previously acquired learning set

Bailey, A. M., & Lee, J. M. (2007) · Brain Research · doi:10.1016/j.brainres.2006.12.028 · Cited by 6

Parafascicular electrical stimulation attenuates nucleus basalis magnocellularis lesion-induced active avoidance retention deficit

Sos-Hinojosa, H., Guillazo‐Blanch, G., Vale-Martı́nez, A., Nadal, R. A., Morgado-Bernal, I., & Martí‐Nicolovius, M. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00060-3 · Cited by 6

Effects of cholinergic agents on spontaneous activity of nucleus basalis magnocellularis neurons in different age rats

Zhang, Y., Ji, Y.-P., & Mei, J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01186-1 · Cited by 6

The nucleus basalis magnocellularis contributes to feature binding in the rat

Botly, L. C. P., & Rosa, E. D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.034 · Cited by 5

Basal Forebrain and Memory

Chiba, A. A., & Quinn, L. K. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00110-8 · Cited by 6

Behavioral effects of neurotrophic factor supplementation in aging

Rose, G. M. (1999) · AGE · doi:10.1007/s11357-999-0001-8 · Cited by 4

Septal medial/diagonal band of Broca citalopram infusion reduces place learning efficiency and alters septohippocampal theta learning-related activity in rats

Hernández, E. S., Cervantes-Alfaro, J. M., Rosales, R. F., Gutiérrez-Guzmán, B. E., Vázquez, M. Á. L., & Olvera‐Cortés, M. E. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114056 · Cited by 3

Neurotoxic Effects, Mechanisms, and Outcome of 192 IgG-Saporin Lesions

Petrosini, L., Bartolo, P. D., & Cutuli, D. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_79 · Cited by 3

Modulatory Influences on the Hippocampus and Entorhinal Cortex

Gupta, K., & Hasselmo, M. E. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1292-2_7 · Cited by 3

Immunotoxic cholinergic lesions in the basal forebrain reverse the effects of entorhinal cortex lesions on conditioned odor aversion in the rat

Ferry, B., Herbeaux, K., Cosquer, B., et al. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.01.007 · Cited by 3

Neurotoxic Effects, Mechanisms, and Outcome of 192-IgG Saporin

Petrosini, L., Bartolo, P. D., & Cutuli, D. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_79 · Cited by 3

p-Chloroamphetamine blocks physostigmine-induced memory enhancement in rats with unilateral nucleus basalis lesions

Santucci, A. C., & Haroutunian, V. H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.09.022 · Cited by 3

Cholinergic Plasticity and the Meaning of Death

McKinney, M., Baskerville, K. A., Personett, D. A., Williams, K., & Gonzales, J. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0282-1_2 · Cited by 3

Intraseptal cholinergic infusions alter memory in the rat: method and mechanism

Chrobak, J. J., Sabolek, H. R., & Bunce, J. G. (2006) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7772-4_5 · Cited by 2

Fornix subdivisions and spatial learning: a diffusion MRI study

Hodgetts, C. J., Postans, M., Williams, A. N., Graham, K. S., & Lawrence, A. D. (2025) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2025.109350 · Cited by 2

Neurotoxic Effects, Mechanisms, and Outcome of 192 IgG-Saporin Lesions

Petrosini, L., Bartolo, P. D., & Cutuli, D. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_79-1 · Cited by 2

Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin

Waite, J. J. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-896-0_3 · Cited by 1

Functional segregation of the human basal forebrain using resting state neuroimagingPreprint

Markello, R. D., Spreng, R. N., Luh, W., Anderson, A. K., & Rosa, E. D. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/211086 · Cited by 1

Introduction to the special issue on extrahippocampal contributions to hippocampal‐dependent memory

Allen, T. A., & Furtak, S. C. (2021) · Hippocampus · doi:10.1002/hipo.23370 · Cited by 1

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Nematbakhsh, M., & Abdollahi, M. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00508-x · Cited by 1

Insulin-like Growth Factor I: Regulation and Interactions During Aging-Induced Cognitive Decline and Impairment Within the Hippocampus

Lund, P. K., Stenvers, K. L., & Gallagher, M. (1998) · Springer eBooks · doi:10.1007/978-88-470-2246-1_4

The Immunolesioned Animal as a Model of Transmitter Dysfunction

Wenk, G. L. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-691-1_4

Cholinergic Basal Forebrain Grafts in Rodent and Nonhuman Primate Models of Alzheimer's Disease

Kordower, J. H., Kordower, H., & Collier, T. J. (1999) · Elsevier eBooks · doi:10.1016/b978-012705070-6/50023-8

Responses in the Basal Forebrain Cholinergic System to Aging

Gu, Z., & Perez-Polo, J. R. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-105-3_12

Major Anatomical Structures

Coward, L. A. (2013) · Springer eBooks · doi:10.1007/978-94-007-7107-9_6

Central Cholinergic Nervous System and Its Correlates

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Cerebellar Contributions to Spatial Learning and Memory: Effects of Discrete Immunotoxic Lesions

Leanza, M. H., Storelli, E., D’Arco, D., de Leo, G., Kleiner, G., Arancio, L., Capodieci, G., Gulino, R., Bava, A., & Leanza, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199553

Etude des déficits de mémoire relationnelle/déclarative au cours du vieillissement chez la souris : approche systémique

Brayda-Bruno, L. (2010) · doi:10.70675/fa61f6e1ze84dz4b30zb31ezaf15f9430425

Effets psychocomportementaux de l’alcoolisation fœtale : modulation pharmacologique et comportementale.

Marche, K. (2011) · theses.fr (ABES) · doi:10.70675/af410416zc0a4z4cd6z8d1ez8ca1ea122684

Untitled work

Finch (1996) · doi:10.1002/(sici)1098-1063(1996)6:5

The role of basal forebrain neurons in tonic and phasic activation of the cerebral cortex

Détári, L., Rasmusson, D. D., & Semba, K. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00084-7 · Cited by 151

Developmental specification of forebrain cholinergic neurons

Allaway, K. C., & Machold, R. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.007 · Cited by 68

Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons

Li, X., Yu, B., Sun, Q., Zhang, Y., Ren, M., Zhang, X., Li, A., Yuan, J., Madisen, L., Luo, Q., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703601115 · Cited by 344

Editorial

Rétaux, S. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.05.001 · Cited by 1

Genetically tagging cholinergic diversity

Luo, J. K., & Pinto, L. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.009 · Cited by 1