Hippocampal lesions impair contextual fear conditioning in two strains of mice.
Abstract
Two different strains of mice, C57BL/6J and BALB/c, with hippocampal, cortical, or sham lesions, underwent contextual fear conditioning. In both strains, contextual fear, as measured by the freezing response, was significantly impaired in hippocampus-lesioned animals compared with sham control animals. Fear conditioning was not affected in the cortical-lesioned group. Moreover, there was a strain difference in fear conditioning: The C57BL/6J mice exhibited freezing more frequently than the BALB/c mice. Consistent with previous hippocampal lesion studies in rats, these results indicate that contextual fear conditioning in mice also requires the intact hippocampus. This study provides a basis for evaluating hippocampal synaptic mechanisms in relation to contextual fear conditioning in widely available gene knockout or transgenic mice.
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The percentage of time spent freezing during the CFM test was used as a measure of CFM, a measure known to be dependent on hippocampal function.
“The percentage of time spent freezing during this trial was used as a measure of CFM, a measure known to be dependent on hippocampal function84.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [84]
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References 22 · Cited by 148
- Authors
- Chen, C., Kim, J. J., Thompson, R. F., & Tonegawa, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Southern California (US)
- Venue
- Behavioral Neuroscience
- Published
- 1996-10
- Volume
- 110
- Issue
- 5
- Pages
- 1177-1180
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2029285462
- Cited by
- 148
- References
- 22
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 10 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 4 · 2012: 6
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampal lesions, contextual fear conditioning, hippocampus, cortical lesions, strain differences, C57BL/6J mice, BALB/c mice, freezing response, knockout mice
- MeSH terms
- Animals, Association Learning, Brain Mapping, Cerebral Cortex, Conditioning, Classical, Fear, Female, Hippocampus, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Motor Activity, Synaptic Transmission, Mental Recall, Social Environment, Species Specificity, Mice
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