Sensitization to the psychomotor stimulant effects of amphetamine: modulation by associative learning
Abstract
The authors investigated the influence of associative pairing of contextual stimuli with amphetamine administration on the expression of psychomotor sensitization. Animals received d-amphetamine or saline in group-specific environments. Amphetamine produced robust behavioral sensitization in all environments, but when an amphetamine challenge was given in a test environment that was novel for some groups but not others, the expression of sensitization was completely context specific. An injection of saline in the amphetamine-paired environment produced a conditional response (CR), but this was quite small compared to the magnitude of the sensitized response, and sensitization remained completely context specific following extinction of the CR. Results are discussed in relation to 3 models of how context may modulate the expression of sensitization: an excitatory conditioning model, an inhibitory conditioning model, and an occasion-setting model.
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According to the interactionist model, there are distinguishable associative and nonassociative components of addiction, and the molecular mechanisms and neural substrates underlying these processes may overlap with those involved in canonical forms of memory.
“According to this model there are distinguishable associative and nonassociative components of addiction, and the molecular mechanisms and neural substrates underlying these processes may overlap with those involved in canonical forms of memory (Anagnostaras and Robinson, 1996; Anagnostaras et al., 2002; Russo et al., 2010).”
From Proteasome phosphorylation regulates cocaine-induced sensitization (2018) · cites this paper as Anagnostaras and Robinson, 1996
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References 86 · Cited by 302
- Authors
- Anagnostaras, S. G., & Robinson, T. E.
- Affiliations
- University of Michigan (US)
- Venue
- Behavioral Neuroscience
- Published
- 1996-12
- Volume
- 110
- Issue
- 6
- Pages
- 1397-1414
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2052078815
- Cited by
- 302
- References
- 86
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 15 · 2013: 11 · 2012: 16
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute on Drug Abuse (R01DA004294)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- locomotor sensitization, amphetamine, associative learning, contextual conditioning, context specificity, conditioned response, extinction, psychostimulants
- MeSH terms
- Amphetamine, Animals, Association Learning, Behavior, Animal, Conditioning, Classical, Dose-Response Relationship, Drug, Male, Motor Activity, Rats, Sprague-Dawley, Rats
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