Impaired trace eyeblink conditioning in bilateral, medial-temporal lobe amnesia.

Abstract

Trace eyeblink classical conditioning was assessed in patients with bilateral medial-temporal amnesia and matched control participants who had previously shown equivalent delay eyeblink conditioning (J. D. E. Gabrieli et al., 1995). The silent trace interval varied for durations of 500, 750, or 1,000 ms in successive sessions separated by at least 2 weeks; extinction trials followed each session. Patients with amnesia produced significantly fewer conditioned responses (CRs) than did control participants at all trace intervals. Both groups produced fewer CRs as the trace interval lengthened. Thus, the temporal lobe memory system in humans makes an essential contribution to normal acquisition in trace, but not delay, classical eyeblink conditioning.

Cites (2)

1. Hippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response.
   Solomon, Paul R, Vander Schaaf, Ellen R., Thompson, Richard F., Weisz, Donald J. · 1986 · Behavioral Neuroscience
2. Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following hippocampal ablation.
   Solomon, Paul R., Moore, John W. · 1975 · Journal of Comparative and Physiological Psychology

Show all 2 references

Cited by (15)

1. Classical conditioning and brain systems: the role of awareness
   Clark, Robert E., Squire, Larry R. · 1998 · Science
2. COGNITIVE NEUROSCIENCE OF HUMAN MEMORY
   Gabrieli, J. D. E. · 1998 · Annual Review of Psychology
3. The Neuroscience of Mammalian Associative Learning
   Fanselow, Michael S., Poulos, Andrew M · 2005 · Annual Review of Psychology
4. An fMRI Study of the Role of the Medial Temporal Lobe in Implicit and Explicit Sequence Learning
   Schendan, Haline E, Searl, Meghan M, Melrose, Rebecca J, Stern, Chantal E · 2003 · Neuron
5. Evolution of declarative memory
   Manns, Joseph R., Eichenbaum, Howard · 2006 · Hippocampus

See all 193