The α-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.
Abstract
Administration of either low or high doses of the alpha-2A adrenergic agonist guanfacine (GFC) to aged monkeys has been shown to improve performance of the delayed-response task, a task linked to the dorsolateral prefrontal cortex (dlPFC). Monkeys treated with higher guanfacine doses also appeared less disinhibited, suggesting enhanced ventromedial-orbital PFC (vmPFC) function. To test this hypothesis, the current study examined the effects of low versus high doses of GFC on reversal of a visual object discrimination task, a task particularly sensitive to vmPFC lesions. The results of this study showed that high (0.1 mg/kg) but not low (0.00001-0.001 mg/kg) doses of GFC significantly improved reversal performance in aged monkeys. These results may be relevant to GFC's calming effects in attention deficit hyperactivity disorder.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Guanfacine enhances various PFC functions in animals, including improvements in working memory, behavioral inhibition, and reduced distractibility.
“Guanfacine enhances various PFC functions in animals, including improvements in working memory (Arnsten et al., 1988), behavioral inhibition (Steere and Arnsten, 1997), and reduced distractibility (Arnsten and Contant, 1992).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Steere and Arnsten, 1997
The citation lists haven’t been fetched yet
References 51 · Cited by 94
- Authors
- Steere, J. C., & Arnsten, A. F. T.
- Affiliations
- Yale University (US)
- ORCID
- Arnsten, A. F. T.
- Venue
- Behavioral Neuroscience
- Published
- 1997-10
- Volume
- 111
- Issue
- 5
- Pages
- 883-891
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2070619076
- Cited by
- 94
- References
- 51
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 8
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- guanfacine, aging, rhesus monkeys, dorsolateral prefrontal cortex, ventromedial prefrontal cortex, dose-dependent effects, attention deficit hyperactivity disorder, cognitive aging
- MeSH terms
- Adrenergic alpha-Agonists, Aging, Animals, Attention, Brain Mapping, Discrimination Learning, Dose-Response Relationship, Drug, Female, Macaca mulatta, Norepinephrine, Pattern Recognition, Visual, Mental Recall, Reversal Learning, Guanfacine, Prefrontal Cortex, Receptors, Adrenergic, alpha-2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
