Double dissociation of function within the hippocampus: Spatial memory and hyponeophagia.
Abstract
Complete and dorsal hippocampal lesions impaired spatial performance on 2 working memory tasks: rewarded alternation on the T maze and matching to position in the water maze. In contrast, ventral hippocampal lesions had no effect on these tasks, even when task difficulty was increased by the introduction of delays. Ventral lesions did resemble complete lesions in reducing anxiety in 3 commonly used tests of anxiety (social interaction, plus-maze, and hyponeophagia). Dorsal lesions also appeared to be anxiolytic in the social interaction and plus-maze tests, but they did not affect hyponeophagia. Complete- and dorsal-lesioned rats displayed hyperactivity, whereas ventral-lesioned rats did not. These results show a double dissociation between dorsal and ventral hippocampal lesions (hyponeophagia vs. spatial memory), suggesting differentiation of function along the septotemporal axis of this structure.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The ventral hippocampus, in contrast to the dorsal hippocampus, is thought to contribute to anxiety-related phenotypes and not spatial memory, per se.
“these studies specifically target alterations in the ventral hippocampus, which in contrast to the dorsal hippocampus, is thought to contribute to anxiety-related phenotypes and not spatial memory, per se.”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Bannerman et al, 2002
The citation lists haven’t been fetched yet
References 56 · Cited by 357
- Authors
- Bannerman, D. M., Deacon, R. M. J., Offen, S., Friswell, J., Grubb, M., & Rawlins, J. N. P.
- Affiliations
- University of Oxford (GB)
- Venue
- Behavioral Neuroscience
- Published
- 2002
- Volume
- 116
- Issue
- 5
- Pages
- 884-901
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2023745778
- Cited by
- 357
- References
- 56
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 17 · 2020: 16 · 2019: 13 · 2018: 15 · 2017: 19 · 2016: 16 · 2015: 16 · 2014: 19 · 2013: 25 · 2012: 19
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampus, dorsal hippocampus, ventral hippocampus, double dissociation, spatial memory, anxiety, working memory, T-maze, water maze, septotemporal axis, hyperactivity, hippocampal lesions
- MeSH terms
- Amphetamine, Central Nervous System Stimulants, Analysis of Variance, Animals, Behavior, Animal, Brain Mapping, Hippocampus, Hyperphagia, Locomotion, Male, Memory, Reaction Time, Space Perception, Time Factors, N-Methylaspartate, Excitatory Amino Acid Agonists, Maze Learning, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
