Transdermal Methylphenidate, Behavioral, and Combined Treatment for Children With ADHD.
Abstract
Stimulant medication and behavioral treatments are evidence-based for children with attention-deficit/hyperactivity disorder, but the combination of the 2 treatments has been understudied. In this investigation, methylphenidate (MPH) was crossed with 2 levels of behavior modification (BMOD) in a summer treatment program. Twenty-seven children with attention-deficit/hyperactivity disorder, aged 6-12, participated. Children received placebo and 3 doses of transdermal MPH (12.5 cm(2), 25.0 cm(2), and 37.5 cm(2)). BMOD was implemented on alternating weeks. Both treatments produced large and significant effects. Combined treatment was superior to either treatment alone. The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations. Consistent with other research, low doses of MPH--even lower than in previous studies--yielded enhanced effects in combination with behavior modification.
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The dosage of OROS-MPH was sufficient to produce large effects on academic seatwork productivity and classroom behavior and detectable effects on test scores.
“However, this dosage was sufficient to produce large effects on academic seatwork productivity and classroom behavior and detectable effects on test scores and has been similarly efficacious in numerous prior studies (Fabiano et al., 2007; Pelham Jr. et al., 2016; Pelham, Burrows-MacLean, et al., 2005; Pelham et al., 2001).”
From The effect of stimulant medication on the learning of academic curricula in children with ADHD: A randomized crossover study. (2022) · cites this paper as Pelham, Burrows-MacLean, et al., 2005
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References 89 · Cited by 150
- Authors
- Pelham, W. E., Burrows-MacLean, L., Gnagy, E. M., Fabiano, G. A., Coles, E. K., Tresco, K. E., Chacko, A., Wymbs, B. T., Wienke, A. L., Walker, K. S., & Hoffman, M. T.
- Affiliations
- University at Buffalo, State University of New York (US)
- ORCID
- Venue
- Experimental and Clinical Psychopharmacology
- Published
- 2005
- Volume
- 13
- Issue
- 2
- Pages
- 111-126
- ISSN
- 1064-1297 (ISSN-L)
- 1936-2293
- OpenAlex
- W2113651750
- Cited by
- 150
- References
- 89
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 6
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental and Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA 11873)
- National Institute of Mental Health (MH62946, R01MH062946, R01MH053554, MH-53554)
- National Institute on Drug Abuse (DA12414, R01DA012414)
- National Institute of Neurological Disorders and Stroke (NS-39087, R01NS039087)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- attention deficit hyperactivity disorder, behavior modification, combined psychotherapy and pharmacotherapy, children, summer treatment program, stimulant medication, treatment effects
- MeSH terms
- Administration, Cutaneous, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Behavior, Behavior Therapy, Child, Combined Modality Therapy, Dose-Response Relationship, Drug, Female, Humans, Male, Methylphenidate, Psychiatric Status Rating Scales, Stress, Psychological, Treatment Outcome
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