The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Reduced model-based decision-making in schizophrenia.
Open accessAbstract
Individuals with schizophrenia have a diminished ability to use reward history to adaptively guide behavior. However, tasks traditionally used to assess such deficits often rely on multiple cognitive and neural processes, leaving etiology unresolved. In the current study, we adopted recent computational formalisms of reinforcement learning to distinguish between model-based and model-free decision-making in hopes of specifying mechanisms associated with reinforcement-learning dysfunction in schizophrenia. Under this framework, decision-making is model-free to the extent that it relies solely on prior reward history, and model-based if it relies on prospective information such as motivational state, future consequences, and the likelihood of obtaining various outcomes. Model-based and model-free decision-making was assessed in 33 schizophrenia patients and 30 controls using a 2-stage 2-alternative forced choice task previously demonstrated to discern individual differences in reliance on the 2 forms of reinforcement-learning. We show that, compared with controls, schizophrenia patients demonstrate decreased reliance on model-based decision-making. Further, parameter estimates of model-based behavior correlate positively with IQ and working memory measures, suggesting that model-based deficits seen in schizophrenia may be partially explained by higher-order cognitive deficits. These findings demonstrate specific reinforcement-learning and decision-making deficits and thereby provide valuable insights for understanding disordered behavior in schizophrenia. (PsycINFO Database Record
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“The literature suggests alterations in the distinct reinforcement learning systems that underlie model-free and model-based decision-making processes in OCD, MDD, and schizophrenia. 59,63,69–74”
From Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making (2024) · cites this paper as [63]
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Ambalavanar, N., Tang, B., Galinato, D. J. A., Spoelma, M. J., Newby, J. M., & Whitton, A. E. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106667
A neural circuit mechanism for abstract free choicePreprint
Gavenas, J., Lan, T., Schurger, A., & Maoz, U. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.29.728548
Transition from model-free to structure-informed decision making in dynamic environmentsPreprint
Yasueda, M., Taira, M., Akam, T., Walton, M. E., & Doya, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.13.744631
Brands, A. M. A., Knauth, K., Mathar, D., Lee, S., Kuzmanovic, B., Tittgemeyer, M., & Peters, J. (2026) · Journal of Behavioral Addictions · doi:10.1556/2006.2025.00424 · Cited by 1
Metadata
- Authors
- Culbreth, A. J., Westbrook, A., Daw, N. D., Botvinick, M., & Barch, D. M.
- Affiliations
- Princeton University (US)
- Venue
- Journal of Abnormal Psychology
- Published
- 2016-08
- Volume
- 125
- Issue
- 6
- Pages
- 777-787
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- PMC
- PMC4980177
- OpenAlex
- W2379192565
- Cited by
- 104
- References
- 60
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 14 · 2023: 10 · 2022: 16 · 2021: 5 · 2020: 7 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 4
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Abnormal Psychology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01 MH066031)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, model-based decision making, reinforcement learning, reward history, computational psychiatry, working memory, IQ, cognitive impairment
- MeSH terms
- Adult, Decision Making, Female, Humans, Individuality, Male, Models, Psychological, Reward, Schizophrenic Psychology
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