The DOI matches its Crossref record.
Classically Conditioned Responses in Opioid and Cocaine Dependence: A Role in Relapse?: (496602006-002)
Abstract
We have shown that conditioned phenomena occur in a number of drug-related settings and that they can be reliably elicited and studied. Our recent work suggests that conditioned craving is an extremely prevalent, if poorly understood, response to drug-related stimuli and that it can occur independent of conditioned withdrawal responses. Our current extinction protocols are effective in reducing the conditioned responses to both opioid and cocaine-related test stimuli. How well this extinction training generalizes to the "real world," is, of course, the crucial clinical question. We are trying to maximize the generalization of extinction through use of realistic, individualized drug "reminders." The final clinical impact of these extinction procedures awaits completion of our ongoing treatment/outcome studies in abstinent opioid and cocaine abusers.
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Citations
Cited by
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,219
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513
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Metadata
- Authors
- Childress, A. R., US Department of Health and Human Services; National Institute on Drug Abuse, McLellan, A. T., Ehrman, R., & O'Brien, C. P.
- Venue
- PsycEXTRA Dataset
- Published
- 1988
- Volume
- 84
- Pages
- 25-43
- OpenAlex
- W2398038833
- Cited by
- 286
- References
- 0
- Type
- dataset
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Classically Conditioned Responses in Opioid and Cocaine Dependence: A Role in Relapse?: (496602006-002). https://app.cochat.ai/papers/10.1037/e496602006-002
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- Childress, A. R., US Department of Health and Human Services; National Institute on Drug Abuse, McLellan, A. T., Ehrman, R., & O'Brien, C. P. (1988). Classically Conditioned Responses in Opioid and Cocaine Dependence: A Role in Relapse?: (496602006-002). PsycEXTRA Dataset. https://doi.org/10.1037/e496602006-002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
