Individual differences in the reinforcing and subjective effects of d-amphetamine: Dimensions of impulsivity.
Open accessAbstract
Previous research has shown a relationship between impulsive personality and the subjective and reinforcing effects of d-amphetamine. Impulsive personality, however, is comprised of multiple dimensions. The association between different dimensions of impulsive personality and the subjective and reinforcing effects of d-amphetamine is unknown. The objective of this study was to assess the independent contributions of the "sensation-seeking" and "impulsivity" dimensions of the impulsive sensation-seeking subscale of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ) to the subjective and reinforcing effects of d-amphetamine. Forty healthy emerging adults varying in scores on the sensation-seeking and impulsivity dimensions of the ZKPQ participated in a double-blind, placebo-controlled, randomized study comprised of 4 2-day blocks. Each 2-day block consisted of a sample day and self-administration day. Subjective effects and physiological measurements were taken prior to, and hourly for 3 hr following, dose administration. On sample days participants were given 8 capsules containing 0, 1, or 2 mg d-amphetamine. On self-administration days participants were able to earn capsules containing the same dose of d-amphetamine that was administered on the previous sample day by responding on a Modified Progressive Ratio Task. The "sensation-seeking" dimension was positively associated with drug taking on the Modified Progressive Ratio Task, subjective effects (e.g., "good effect"), and heart rate. However, no clear relationship between the "impulsivity" dimension and outcome measures was observed. In conclusion, these data suggest that the narrow sensation-seeking dimension of impulsive sensation-seeking is associated with initial drug liking and drug taking behavior and may be a key predictor of drug use initiation. (PsycINFO Database Record
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AMP does not have consistent effects on subjective measures.
“AMP does not have consistent effects on subjective measures”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Harvanko et al., 2016
The Discussion states that 8 or 16 mg d-amphetamine produced consistent increases in subjective effects. The Results (“d-Amphetamine Effects”) also report dose-related increases across several self-report ratings. Our copy provides section labels but no page numbers. (LLM, conf=0.90)
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Experimental — accuracy not yet measuredPersonality traits influence the subjective effects of amphetamine.
“several studies also reported that personality trait influence the subjective effects of AMP (Allen & Gabbay, 2013; Harvanko et al., 2016; Kirkpatrick et al., 2013; see White, 2017 for review).”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Harvanko et al., 2016
The inconsistency in AMP's subjective effects may be linked to between-person variations in personality traits such as sensation seeking.
“several studies suggested that this inconsistency may be linked to between‐person variations in personality traits such as sensation seeking”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Harvanko et al., 2016
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- Authors
- Harvanko, A., Martin, C., Lile, J., Kryscio, R., & Kelly, T. H.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Kelly, Thomas H.
- Venue
- Experimental and Clinical Psychopharmacology
- Published
- 2016-12
- Volume
- 24
- Issue
- 6
- Pages
- 436-446
- ISSN
- 1064-1297 (ISSN-L)
- 1936-2293
- PMC
- PMC5152693
- OpenAlex
- W2560308169
- Cited by
- 14
- References
- 34
- Citations by year
- 2025: 3 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Experimental and Clinical Psychopharmacology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (P50 DA05312, UL1TR000117, and K02 DA031766)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Keywords
- d-amphetamine, impulsivity, sensation seeking, impulsive sensation seeking, subjective effects, reinforcement effect, self-administration, drug liking, heart rate, Zuckerman-Kuhlman Personality Questionnaire, emerging adults, drug initiation, personality factors
- MeSH terms
- Adult, Amphetamine, Double-Blind Method, Female, Humans, Impulsive Behavior, Individuality, Male, Personality, Psychometrics, Reinforcement, Psychology, Amphetamine-Related Disorders, Young Adult
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