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Life stress and major depression: The mysteries of recurrences.
Abstract
Approximately half of the people who suffer a major depressive episode for the first time experience recurrences, while the other half do not. Among the initially depressed, however, who will have recurrences remains a mystery, and cannot be forecasted with any statistical or clinical confidence. It is well documented, though, that highly stressful life events commonly precede first episodes of major depression, and that these experiences become progressively less common prior to recurrences. Determining the basis for this consistent empirical observation holds promise for discovering among the initially depressed who will become recurrent, helping to solve the current-day conundrum of recurrences. The present article has 2 overarching objectives. First, we evaluate stress sensitization, the prevailing theory for explaining the decreasing association of major life events with successive recurrences. Conceptual gaps, discrepancies, and misunderstandings are found for understanding the decreasing association, as well as for understanding recurrences. Research practices and logical errors also are exposed that compromise the integrity of the existing empirical record. Second, alternative theoretical accounts are proposed to explain the decreasing association of major life stress with recurrences. Two "dual pathway models" provide viable alternative explanations, fill in existing theoretical gaps, and supply additional advantages for understanding life stress, depression, and recurrences. Recommendations are made for evaluating the 3 respective models. In closing, limitations and remaining questions are discussed for discovering who, early in the lifetime course of major depression, is likely to have a lifetime of repeated recurrences. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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“Epidemiological studies indicate that environmental factors are strongly associated with the risk of developing MDD and other stress-related disorders.18–22”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [18]
In the citing paper
“severe stressful life events frequently precede the onset of a first episode of MDD150.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [150]
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BackgroundSex-specific neural responses to acute psychosocial stress in depression
Dong, D., Ironside, M., Belleau, E. L., Sun, X., Cheng, C., Xiong, G., Nickerson, L. D., Wang, X., Yao, S., & Pizzagalli, D. A. (2022) · Translational Psychiatry · doi:10.1038/s41398-021-01768-y · Cited by 52
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BackgroundLunansky, G., van Borkulo, C. D., & Borsboom, D. (2020) · European Journal of Personality · doi:10.1002/per.2263 · Cited by 58
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BackgroundXu, Y. J., Li, R., Hu, C., He, Y., Zhang, X., & Li-na, J. (2024) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2024.03.003 · Cited by 37
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Samad, N., Manzoor, N., Muneer, Z., Bhatti, S. A., & Imran, I. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00789-2 · Cited by 34
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Buckman, J. E. J., Stott, J. C. H., Main, N., Antonie, D., Singh, S., Naqvi, S. A., Aguirre, E., Wheatley, J., Cirkovic, M., Leibowitz, J., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721004773 · Cited by 35
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Xiong, G., Dong, D., Chang, C., Jiang, Y., Sun, X., He, J., Li, C., Gao, Y., Zhong, X. B., Zhao, H., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102871 · Cited by 26
Xu, Q., Qiao, Z., Kan, Y., Wan, B., Qiu, X., & Yang, Y. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120018 · Cited by 33
Wu, S. M., Chen, J., Chang, C.-Y., et al. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.736304 · Cited by 24
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BackgroundLiu, Q., & Cole, D. A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.06.012 · Cited by 28
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BackgroundAndrews, P. W., Maslej, M. M., Thomson, J. A., & Hollon, S. D. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101927 · Cited by 16
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Kato, T. (2020) · Anxiety Stress & Coping · doi:10.1080/10615806.2020.1795139 · Cited by 12
Schricker, I. F., Nayman, S., Reinhard, I., & Kuehner, C. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104383 · Cited by 9
Ezawa, I. D., Robinson, N., & Hollon, S. D. (2024) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-080822-040442 · Cited by 9
Zhong, L., Xu, Z., Li, X., Law, R., Wang, Y., & Zhu, M. (2025) · Tourism Management · doi:10.1016/j.tourman.2025.105221 · Cited by 12
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BackgroundSuk, F., Hsu, F.-Y., Hsu, M.-H., Chiu, W., Fang, C.-C., Chen, T.-L., & Liao, Y. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122327 · Cited by 7
Xu, G., Yuan, M., He, H., Jin, Y., Li, X., Yan, H., Liu, G., Wu, Z., Zhang, X., Chen, Y., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03344-y · Cited by 12
Reimann, G. E., Stier, A. J., Moore, T. M., Durham, E. L., Jeong, H. J., Cardenas‐Iniguez, C., Dupont, R. M., Pines, J. R., Berman, M. G., Lahey, B. B., et al. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.07.007 · Cited by 8
Eielsen, M., Ulvenes, P., Røssberg, J. I., Høstmælingen, A., Soma, C. S., & Wampold, B. E. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04381-5 · Cited by 11
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BackgroundTosato, S., Bonetto, C., Santi, K. D., Lasalvia, A., Gennarelli, M., Cristofalo, D., Bertani, M., Ruggeri, M., & on behalf of the PICOS-Veneto Group (2023) · Genes · doi:10.3390/genes14020350 · Cited by 9
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BackgroundJiale, X. I. A. O., Shen, Z., Xiaoyan, L. I., & Danhua, L. I. N. (2023) · Acta Psychologica Sinica · doi:10.3724/sp.j.1041.2023.00978 · Cited by 9
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Gorham, L. S., Sadeghi, N., Eisner, L., Taigman, J., Haynes, K. T., Qi, K., Camp, C., Fors, P. Q., Rodriguez, D., McGuire, J., et al. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13547 · Cited by 7
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BackgroundSharma, G. K., Rahmatkar, S. N., Rana, A. K., Sharma, P., Patial, V., Singh, D., & Chowdhury, S. R. (2023) · IEEE Sensors Journal · doi:10.1109/jsen.2023.3266235 · Cited by 4
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Dong, S., Wang, Y., Ma, X., Liu, M., Li, M., Luo, M., Liu, Y., Liu, J., & Yu, X. (2025) · Journal of Environmental Psychology · doi:10.1016/j.jenvp.2025.102721 · Cited by 5
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Taylor, W. D., Gerlach, A., Szymkowicz, S. M., Gujral, S., & Andreescu, C. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02324-2 · Cited by 3
Rojas, R., Behnke, A., & Hautzinger, M. (2021) · Cognitive Therapy and Research · doi:10.1007/s10608-021-10280-y · Cited by 3
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Chen, J., Li, S., Yang, S., Chen, Y., Ndenkeh, J. J. N., Batubara, I. M. S., Zhu, L., Liu, J., Pan, X., Zou, Z., et al. (2025) · European Psychiatry · doi:10.1192/j.eurpsy.2025.10058 · Cited by 4
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Ising, M., Holsboer, F., Myhsok, M., & Müller‐Myhsok, B. (2025) · Pharmacopsychiatry · doi:10.1055/a-2508-5834 · Cited by 2
Cummins, K. M., Brumback, T., Corrales, C., Nooner, K. B., Brown, S. A., & Clark, D. B. (2024) · PLOS Global Public Health · doi:10.1371/journal.pgph.0003545 · Cited by 1
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Giglberger, M., Peter, H. L., Henze, G., Bärtl, C., Konzok, J., Kirsch, P., Kudielka, B. M., Kreuzpointner, L., & Wüst, S. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70019 · Cited by 1
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Brink, H. V., McCormick, K. C., Lujan, M. E., Chang, J. P., Ipp, L. S., Mudrak, E. L., Alladeen, A., Lamar, H., Kim, J. Y., & Mendle, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1551958 · Cited by 4
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Cantor-Cutiva, L. C., Carrillo-González, A., Yousef, A. M., Berardi, M. L., & Hunter, E. J. (2026) · Depression and Anxiety · doi:10.1155/da/5592230 · Cited by 2
“The etiology of depressive disorders is widely recognized as multifactorial, involving a complex interplay of genetic predispositions, environmental in fl uences, and lifestyle-related factors [6, 7].”
Kato, T. (2026) · International Journal of Psychology · doi:10.1002/ijop.70245 · Cited by 1
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Amestoy, M. E., & Fiocco, A. J. (2021) · Journal of Student Research · doi:10.47611/jsr.v10i3.1281 · Cited by 5
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BackgroundSoberano, J. I. D., Siongco, K. L. L., Kabristante, E. I. A., Leyva, E. W. A., & Evangelista, L. S. (2021) · PubMed · Cited by 1
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Emara, A., Abdelraof, A. I., & Razek, R. A. A. (2023) · Assiut Scientific Nursing Journal · doi:10.21608/asnj.2023.243260.1698 · Cited by 1
Mathisen, J., Nguyen, T., Madsen, I. E. H., Xu, T., Jensen, J. H., Sørensen, J. K., Rugulies, R., & Rod, N. H. (2024) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796024000167 · Cited by 5
“These findings are in accordance with the stress sensitisation theory, the dominant theory of stress in recurrent depression, which posits that non-major stressors can trigger subsequent episodes (Monroe et al. , 2019).”
BackgroundResultWang, Y., Wei, S., Li, Y., & Jiang, X. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119980 · Cited by 1
Wong, S. M. Y., Chen, E. Y. H., Suen, Y. N., van Os, J., Jones, P. B., McGorry, P. D., Lam, T., Morgan, C., McDaid, D., Sham, P. C., et al. (2025) · Psychological Medicine · doi:10.1017/s0033291725102468 · Cited by 1
“Cognitive models of enduring depression have suggested that, whereas exter-nal factors might trigger the onset of depression, intrinsic vulnerabilities play a stronger role in its maintenance (Lewinsohn et al., 1999; Monroe et al., 2019; Teasdale, 1988).”
The Functional Domain of Self-Other Regulation
Lorenzini, N., Fonagy, P., & Luyten, P. (2021) · Depression and personality · doi:10.1007/978-3-030-70699-9_4
(2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev-cp-6-030910-100001
Widiger, T. A., & Cannon, T. D. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-cp-9-031513-100001
Amestoy, M. E., & Fiocco, A. J. (2024) · doi:10.32920/25569636.v1
Amestoy, M. E., & Fiocco, A. J. (2024) · doi:10.32920/25569636
Grogans, S. E., DeYoung, K. A., Hur, J., Anderson, A. S., Islam, S., Kim, H. C., Wedlock, J., Craig, L. E., Tillman, R. M., Das, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.11.659182
“Our findings, which leveraged neuroimaging data from individuals who were free from internalizing disorders at baseline, weigh against this possibility.”
Depressive symptoms predict divergent trajectories of well-being in US adults
Lyman, C., Ong, A. D., & Rottenberg, J. A. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00705-6
“By contrast, people whose symptoms began in response to addressable life stressors may be more likely to experience well-being turning points 51 .”
Adebahr, R., Savard, J., Åkerstedt, U., Byström, M., Sparre, C., Hadding, C., Öberg, K. G., & Jokinen, J. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1618162
“…are the basic hallmark of trauma-and stress-related disorders (e.g., acute stress disorder, adjustment disorder, and post-traumatic stress disorder) and have been associated with the onset of major depressive disorder and a risk of developing or relapsing in substance use disorders (20, 21).”
Ackerman, S. L., & Moore, M. T. (2026) · International Journal of Cognitive Behavioral Therapy · doi:10.1007/s41811-026-00277-4
“…group of individuals who will experience one episode of depression, only, in their lifetimes (i.e., the depression capable ) and a second group that will experience recurrent episodes (i.e., the recurrence prone ; see Monroe & Harkness, 2022, and Monroe et al., 2019 for more detailed reviews).”
Loneliness and social support mediate stress–depression in truck drivers
Zhang, J., Wang, S., Chen, S., Feng, C., & Liu, J. (2026) · Occupational Medicine · doi:10.1093/occmed/kqag013
Evers, K. C., Borsboom, D., Fried, E. I., Hasselman, F., Bartos̆, F., & Waldorp, L. (2026) · Communications Psychology · doi:10.1038/s44271-026-00394-y
Thompson, M. J., Ehrhardt, A. D., Kelly, R. J., & El‐Sheikh, M. (2026) · Child Development · doi:10.1093/chidev/aacag073
“Stress sensitization frameworks, therefore, caution against inferring sensitization from static between-person differences in vulnerability (Monroe et al., 2019; Stroud, 2020).”
InfluentialGiglberger, M., Henze, G., Bärtl, C., Peter, H. L., Konzok, J., Zänkert, S., Kirsch, P., Frank, J., Kudielka, B. M., Walter, H., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9858017/v1
Jonassen, R., Øverli, Ø., Hilland, E., Nilsen, H. L., Esbensen, Q. Y., Lirussi, L., Heiberg, H., Rønning, K. H., Gorissen, M. E. E., Kraft, B., et al. (2026) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2026.100363
Ma, Y., Guan, Q., Ji, J., Chen, Z., Ji, Q., Ren, G., Sun, M., Lin, X., & Zhou, H. (2026) · British Journal of Hospital Medicine · doi:10.31083/bjhm56188
Metadata
- Authors
- Monroe, S. M., Anderson, S. F., & Harkness, K. L.
- Venue
- Psychological Review
- Published
- 2019-11
- Volume
- 126
- Issue
- 6
- Pages
- 791-816
- ISSN
- 0033-295X (ISSN-L)
- 1939-1471
- OpenAlex
- W2967472886
- Cited by
- 102
- References
- 0
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 8 · 2021: 22 · 2020: 10
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Review (publishedVersion)
- PubMed (publishedVersion)
- Funders
- John Simon Guggenheim Foundation
- William K. Warren Foundation
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- major depressive disorder, depression recurrence, life events, stress sensitization, dual-pathway model, first-episode depression
- MeSH terms
- Depressive Disorder, Major, Major Depressive Disorder, Humans, Models, Psychological, Psychological Theory, Stress, Psychological, Disease Progression
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