Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice

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Items 101–178 of 178

1. Stem cell transplantation demonstrates that Sox6 represses εy globin expression in definitive erythropoiesis of adult mice
   Orit Cohen‐Barak, Drew T. Erickson, Michael Badowski, Deborah A. Fuchs, Christine L. Klassen, David T. Harris, Murray H. Brilliant · 2007 · Experimental Hematology
2. Co-Regulated Genes and Gene Clusters
   Sergey V. Razin, Elena S. Ioudinkova, Omar L. Kantidze, Olga V. Iarovaia · 2021 · Genes
3. Genome Architecture of the Human β-Globin Locus Affects Developmental Regulation of Gene Expression
   Susanna Harju-Baker, Patrick A. Navas, George Stamatoyannopoulos, Kenneth R. Peterson · 2005 · Molecular and Cellular Biology
4. Phylogenetic comparisons suggest that distance from the locus control region guides developmental expression of primate β-type globin genes
   Robert M. Johnson, Tom Prychitko, Deborah L. Gumucio, Derek E. Wildman, Monica Uddin, Morris Goodman · 2006 · Proceedings of the National Academy of Sciences
5. CRISPR Double Cutting through the Labyrinthine Architecture of 3D Genomes
   Haiyan Huang, Qiang Wu · 2016 · Journal of genetics and genomics/Journal of Genetics and Genomics
6. Short-chain fatty acid–mediated effects on erythropoiesis in primary definitive erythroid cells
   Himanshu Bhatia, Jennifer L. Hallock, Amrita Dutta, Shay Karkashon, Lauren Sterner, Toru Miyazaki, Ann Dean, Jane Alison Little · 2009 · Blood
7. An Evolutionarily Conserved TNF-α–Responsive Enhancer in the Far Upstream Region of Human CCL2 Locus Influences Its Gene Expression
   Gregory B. Bonello, Minh-Hieu Pham, Kazi Begum, José A. Sigala, Kavithalakshmi Sataranatarajan, Srinivas Mummidi · 2011 · The Journal of Immunology
8. Small molecule therapeutics to treat the β-globinopathies
   Lei Yu, Greggory Myers, James Douglas Engel · 2020 · Current Opinion in Hematology
9. Enhancer Function in the 3D Genome
   Razin, Sergey V., Ulianov, Sergey V., Iarovaia, Olga V. · 2023 · Genes
10. Domains of α- and β-globin genes in the context of the structural-functional organization of the eukaryotic genome
    Sergey V. Razin, Sergey V. Ulianov, Elena S. Ioudinkova, Ekaterina S. Gushchanskaya, Alexey A. Gavrilov, Olga V. Iarovaia · 2012 · Biochemistry (Moscow)
11. Transgenic mice carrying yeast artificial chromosomes
    Kenneth R. Peterson · 2003 · Expert Reviews in Molecular Medicine
12. Understanding fundamental principles of enhancer biology at a model locus
    Mira T. Kassouf, Seren Ford, Joseph Blayney, Douglas R. Higgs · 2023 · BioEssays
13. The α-globin super-enhancer acts in an orientation-dependent manner
    Mira T. Kassouf, Helena S. Francis, Matthew E. Gosden, Maria Suciu, Damien J. Downes, Caroline L. Harrold, Martin Larke, A. Marieke Oudelaar, Lucy Cornell, Joseph Blayney et al. · 2025 · Nature Communications
14. Persistent Fetal γ-Globin Expression in Adult Transgenic Mice following Deletion of Two Silencer Elements Located 3′ to the Human Aγ-Globin Gene
    Maria Gazouli, Eleni Z. Katsantoni, Theodoros Kosteas, Nicholas P. Anagnou · 2009 · Molecular Medicine
15. Non-erythroid Genes Inserted on Either Side of Human HS-40 Impair the Activation of Its Natural α-Globin Gene Targets without Being Themselves Preferentially Activated
    Corinne Espéret, Sandrine Sabatier, Marie‐Alice Deville, Roland Ouazana, Eric E. Bouhassira, Jacqueline Godet, François Morlé, Agnès Bernet · 2000 · Journal of Biological Chemistry
16. The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period
    Hitomi Matsuzaki, Shokichi Sugihara, Keiji Tanimoto · 2023 · Epigenetics & Chromatin
17. 5′HS5 of the Human β-globin Locus Control Region Is Dispensable for the Formation of the β-globin Active Chromatin Hub
    Ping Kei Chan, Albert Wai, Sjaak Philipsen, KC Tan-Un · 2008 · PLoS ONE
18. Energetic Differences at the Subunit Interfaces of Normal Human Hemoglobins Correlate with Their Developmental Profile
    Lois R. Manning, Janice Russell, Anthony M. Popowicz, Robert S. Manning, Julio Cesar Padovan, James M. Manning · 2009 · Biochemistry
19. Factors Binding a Non-classical Cis-element Prevent Heterochromatin Effects on Locus Control Region Activity
    Faith J. Harrow, Jeanne U. Amuta, Shauna R. Hutchinson, Frank Akwaa, Benjamin D Ortiz · 2004 · Journal of Biological Chemistry
20. Transient establishment of imprinted DNA methylation of transgenic human IC1 sequence in mouse during the preimplantation period
    Katsuhiko Hirakawa, Hitomi Matsuzaki, Keiji Tanimoto · 2020 · Human Molecular Genetics
21. Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ -Globin Gene Expression
    Yong Shen, Maclean Bassett, Aishwarya Gurumurthy, Rukiye Nar, Isaac J. Knudson, Cameron R. Guy, Alex Perez, Russell W. Mellen, Masatoshi Ikeda, Mir Ahamed Hossain et al. · 2018 · Molecular and Cellular Biology
22. Linear Distance from the Locus Control Region Determines ε-Globin Transcriptional Activity
    Motoshi Shimotsuma, Hitomi Matsuzaki, Osamu Tanabe, Andrew Campbell, James Douglas Engel, Akiyoshi Fukamizu, Keiji Tanimoto · 2007 · Molecular and Cellular Biology
23. Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
    Jared R. Stees, Fred Varn, Suming Huang, John Strouboulis, Jörg Bungert · 2012 · Biology
24. Evolution of the Genome 3D Organization: Comparison of Fused and Segregated Globin Gene Clusters
    Anastasia P Kovina, Natalia V. Petrova, Ekaterina S. Gushchanskaya, K. V. Dolgushin, Evgeny S. Gerasimov, Aleksandra A. Galitsyna, Aleksey A. Penin, Ilya M. Flyamer, Elena S. Ioudinkova, Alexey A. Gavrilov et al. · 2017 · Molecular Biology and Evolution
25. Promoters of the murine embryonic β-like globin genes Ey and β h1 do not compete for interaction with the β-globin locus control region
    Xiao Hu, Michael Bulger, Julia N. Roach, Susan K. Eszterhas, Emmanuel N. Olivier, Eric E. Bouhassira, Mark T. Groudine, Steven Fiering · 2003 · Proceedings of the National Academy of Sciences
26. Autonomous Silencing as Well as Competition Controls γ-Globin Gene Expression during Development
    Man Yu, Hemei Han, Ping Xiang, Qiliang Li, George Stamatoyannopoulos · 2006 · Molecular and Cellular Biology
27. Mechanistic insights into the evolution of the differential expression of tandemly arrayed cone opsin genes in zebrafish
    Taro Tsujimura · 2020 · Development Growth & Differentiation
28. Long-term and efficient expression of human β-globin gene in a hematopoietic cell line using a new site-specific integrating non-viral system
    Kianoush Dormiani, H Mir Mohammad Sadeghi, Hojjat Sadeghi‐Aliabadi, Kamran Ghaedi, Mohsen Forouzanfar, Hossein Baharvand, Mohammad Hossein Nasr‐Esfahani · 2015 · Gene Therapy
29. Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high‐level expression of a human β‐globin transgene in a centromeric region
    Sung-Hae Lee Kang, Padraic P. Levings, Félicie Faucon Andersen, Philip J. Laipis, Kenneth I. Berns, Robert Zori, Jörg Bungert · 2004 · Genes to Cells
30. Building regulatory landscapes: enhancer recruits cohesin to create contact domains, engage CTCF sites and activate distant genes
    Rinzema, Niels J., Sofiadis, Konstantinos, Tjalsma, Sjoerd J. D., Verstegen, Marjon J.A.M., Oz, Yuva, Valdes-Quezada, Christian, Felder, Anna-Karina, Filipovska, Teodora, van der Elst, Stefan, de Andrade dos Ramos, Zaria et al. · 2021
31. Gene order in human α‐globin locus is required for their temporal specific expressions
    Yi Tang, Zhao Wang, Yue Huang, De‐Pei Liu, Guang Liu, Wei Shen, Xiaobin Tang, Dong-Xiao Feng, Chih‐Chuan Liang · 2005 · Genes to Cells
32. Evidence for a Bigenic Chromatin Subdomain in Regulation of the Fetal-to-Adult Hemoglobin Switch
    Hugues Beauchemin, Marie Trudel · 2008 · Molecular and Cellular Biology
33. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells
    Idowu Asegame Aimola, Hajiya Mairo Inuwa, Andrew Jonathan Nok, Aisha Indo Mamman, James J. Bieker · 2016 · European Journal of Pharmacology
34. All of the human β‐type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice
    Eiichi Okamura, Hitomi Matsuzaki, Andrew Campbell, James Douglas Engel, Akiyoshi Fukamizu, Keiji Tanimoto · 2009 · The FASEB Journal
35. Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain
    Yike Huang, Marjon J.A.M. Verstegen, Sjoerd J. D. Tjalsma, Peter H.L. Krijger, Kavvya Gupta, Minhee Park, Alistair Nicol Boettiger, Wouter L. de Laat · 2025 · Genes & Development
36. DNase I Hypersensitivity and ϵ-Globin Transcriptional Enhancement Are Separable in Locus Control Region (LCR) HS1 Mutant Human β-Globin YAC Transgenic Mice
    Motoshi Shimotsuma, Eiichi Okamura, Hitomi Matsuzaki, Akiyoshi Fukamizu, Keiji Tanimoto · 2010 · Journal of Biological Chemistry
37. Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression
    Alice T Trinh, Bret Gene Ball, Erin L. Weber, Timothy K. Gallaher, Zoya Gluzman‐Poltorak, French Anderson, Lena A Basile · 2009 · Genetic Vaccines and Therapy
38. Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the γ-globin gene in adult erythropoiesis
    Ping Xiang, Hemei Han, Gráinne Barkess, Ivan A. Olave, Xiangdong Fang, Wenxuan Yin, George Stamatoyannopoulos, Qiliang Li · 2005 · Human Molecular Genetics
39. Further understanding of the β‐globin locus regulation at the molecular level: looping or linking models?
    Yi Tang, De‐Pei Liu, Chih‐Chuan Liang · 2002 · Genes to Cells
40. Impact of Transgenic Technologies on Functional Genomics
    Cooduvalli S. Shashikant, Frank H. Ruddle · 2003 · Current Issues in Molecular Biology
41. The regulatory network controlling β-globin gene switching
    Wei Shen, De‐Pei Liu, Chih‐Chuan Liang · 2001 · Molecular Biology Reports
42. αβ T‐cell development is not affected by inversion of TCRβ gene enhancer sequences: polar enhancement of gene expression regardless of enhancer orientation
    Fang Huang, Olivier Cabaud, Christophe Verthuy, Anne‐Odile Hueber, Pierre Ferrier · 2003 · Immunology
43. Multipartite super-enhancers function in an orientation-dependent manner
    Mira T. Kassouf, Helena S. Francis, Matthew E. Gosden, Maria Suciu, Damien J. Downes, Caroline L. Harrold, Martin Larke, A. Marieke Oudelaar, Lucy Cornell, Joseph Blayney et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
44. Epigenetic Regulation of Erythropoiesis: From Developmental Programs to Therapeutic Targets
    Ninos-Ioannis Vasiloudis, Kiriaki Paschoudi, Christina Beta, Grigorios Georgolopoulos, Nikoletta Psatha · 2025 · International Journal of Molecular Sciences
45. Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers
    Anna-Karina Felder, Sjoerd J. D. Tjalsma, Han J. M. P. Verhagen, Rezin Majied, Marjon J.A.M. Verstegen, Thijs C. J. Verheul, Jeffrey van Haren, Rebecca Mohnani, Richard Gremmen, Peter H.L. Krijger et al. · 2025 · Blood
46. CTCF-dependent enhancer-blocking by alternative chromatin loop formation
    Chunhui Houa, Ann Deana · 2016
47. Cluster specific regulation pattern of upstream regulatory elements in human α- and β-globin gene clusters
    Yi Tang, Yue Huang, Wei Shen, Guang Liu, Zhao Wang, Xiaobin Tang, Dong-Xiao Feng, De‐Pei Liu, Chih‐Chuan Liang · 2007 · Experimental Cell Research
48. In vivo Modulation of Human β-globin Gene Switching
    Keiji Tanimoto · 2000 · Trends in Cardiovascular Medicine
49. An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain
    Emmanuel Debrand, Lyubomira Chakalova, Joanne Miles, Yan-Feng Dai, Beatriz Goyenechea, Sandra Dye, Cameron S. Osborne, Alice Horton, Susanna Harju-Baker, Ryan Charles Pink et al. · 2019 · PLoS ONE
50. Evolution of α- and β-Globin genes and their regulatory systems in light of the hypothesis of domain organization of the genome
    Olga V. Iarovaia, Elena S. Ioudinkova, Natalia V. Petrova, K. V. Dolgushin, A. V. Kovina, А. В. Нефедочкина, Yegor S Vassetzky, Sergey V. Razin · 2014 · Biochemistry (Moscow)
51. Insulators in vertebrates: regulatory mechanisms and chromatin structure
    Sergey V. Ulianov, Elena N. Markova, Alexey A. Gavrilov, Sergey V. Razin · 2012 · Biopolymers and Cell
52. Reporter Constructs Showing Proper Globin Gene Switching in Cultured Erythroid Cell Lines
    Nam‐Gyun Kim, Ji Hyung Chae, Soo Young Choe, Chul Geun Kim · 2000 · Molecules and Cells
53. Locus Control Regions: Description in the LCR-TRRDatabase
    Olga A. Podkolodnaya, V. G. Levitsky, N. L. Podkolodnyy · 2001 · Molecular Biology
54. Tandem Directional CTCF Sites Balance Protocadherin Promoter Usage
    Qiang Wu, Ya Guo, Yujia Lu, Jingwei Li, Yonghu Wu, Zhilian Jia · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
55. Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance matters
    Anna-Karina Felder, Sjoerd J. D. Tjalsma, Han J. M. P. Verhagen, Rezin Majied, Marjon J.A.M. Verstegen, Thijs C. J. Verheul, Rebecca Mohnani, Richard Gremmen, Peter H.L. Krijger, Sjaak Philipsen et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
56. Genome Domains and Domain Regulatory Elements
    Elena S. Ioudinkova, Sergey V. Razin · 2002 · Molecular Biology
57. The epigenetic eraser LSD1 lies at the apex of a reversible erythroid to myeloid cell fate decision
    Lei Yu, Greggory Myers, Chia-Jui Ku, Emily Schneider, Yu Wang, Sharon A Singh, Natee Jearawiriyapaisarn, Andrew D. White, Takashi Moriguchi, Rami N. Khoriaty et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
58. Studying Evolution Using Genome Sequence Data
    Jeffrey G. Lawrence · 2014 · ASM Press eBooks
59. Gene Therapy for Platelet Disorders
    David A. Wilcox · 2019 · Elsevier eBooks
60. Gene Therapy for Platelet Disorders
    David A. Wilcox · 2012 · Elsevier eBooks
61. Locus control regions
    Xiangdong Fang, Kenneth R. Peterson, Qiliang Li, George Stamatoyannopoulos · 2003 · New comprehensive biochemistry
62. The Future of Human Cytogenetics
    Orlando J. Miller, Eeva Therman · 2001 · Springer eBooks
63. Gene Expression in Mammalian Cells
    Félix Recillas Targa, Georgina Guerrero, Martín Escamilla-Del-Arenal, Héctor Rincón‐Arano · 2010 · Genomics
64. Locus Control Regions, Human
    Nancy E. Cooke, Stephen A. Liebhaber · 2002 · Wiley Encyclopedia of Molecular Medicine
65. Molekulare Ursachen der Störungen der Hämoglobinsynthese beim Embryo, Fetus und Neugeborenen
    Christof Dame, Jörg Bungert · 2005 · Springer eBooks
66. Beta-Globin Gene Regulation and Nuclear Organisation
    Jurgen A. Kooren · 2007 · EUR Research Repository (Erasmus University Rotterdam)
67. Globin Gene Expression: Role of Transcription Factors
    Alireza Fotouhi Ghiam · 2009
68. Characterization of an ectopic beta-globin LCR: Good neighbors and a distant friend
    Daan Noordermeer · 2009 · RePub (Erasmus University Rotterdam)
69. Gene Therapy for Platelet Disorders
    David A. Wilcox, Gilbert White · 2007 · Elsevier eBooks
70. Distal regulation of the interferon gamma locus
    Patrick L. Collins · 2011
71. Genetic Vaccines and Therapy
    Alice T Trinh, Bret Gene Ball, Erin L. Weber, Timothy K. Gallaher, Zoya Gluzman‐Poltorak, Lena A Basile · 2015
72. Enhancers
    James Douglas Engel · 2002 · Wiley Encyclopedia of Molecular Medicine
73. Additional file 1 of Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection
    Zhilian Jia, Jingwei Li, Xiao Ge, Wu, Yonghu, Guo, Ya, Wu, Qiang · 2020 · Figshare
74. Additional file 2 of Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection
    Zhilian Jia, Jingwei Li, Xiao Ge, Wu, Yonghu, Guo, Ya, Wu, Qiang · 2020 · Figshare
75. Additional file 3 of Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection
    Zhilian Jia, Jingwei Li, Xiao Ge, Wu, Yonghu, Guo, Ya, Wu, Qiang · 2020 · Figshare
76. Functional characterization of the TRRAP pseudokinase and its chaperone TTT during transcriptional regulation in colorectal cancer
    Dylane Detilleux · 2018 · theses.fr (ABES)
77. Multiple roles for the transcription factors Sox6 and jumonji in mouse hematopoiesis
    Drew T. Erickson · 2006 · UA Campus Repository (The University of Arizona)
78. Epigenetic Gene Regulation—Lessons from Globin
    Ann Dean, Steven Fiering · 2008 · Springer eBooks