Intracellular pH and Activation of Sea Urchin Eggs after Fertilisation
Abstract
The intracellular pH of the sea urchin embryo increases 0.3 pH units between 1 and 4 min after fertilisation. The increase in pH is required for initiating development. The increase results from an exchange of extracellular Na+ for intracellular H+.
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Cells are capable of buffering against extracellular reductions in pH to maintain alkaline pH of the cytoplasm.
“Cells are capable of buffering against extracellular reductions in pH to maintain alkaline pH of the cytoplasm (Johnson et al., 1976; L’allemain et al., 1984; Lindström and Sehlin, 1984; Pouyssegur et al., 1985; McBrian et al., 2013).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Johnson et al., 1976
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References 17 · Cited by 556
- Authors
- Johnson, J. D., Epel, D., & Paul, M.
- Affiliations
- Scripps Institution of Oceanography (US)
- University of Victoria (CA)
- Venue
- Nature
- Published
- 1976-08
- Volume
- 262
- Issue
- 5570
- Pages
- 661-664
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2046239497
- Cited by
- 556
- References
- 17
- Citations by year
- 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 38.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- intracellular pH, sea urchin eggs, fertilisation (biology), embryo activation, Na+/H+ exchange, embryonic development
- MeSH terms
- Amiloride, Ammonia, Animals, Biological Transport, Cell Division, Cytoplasm, Female, Fertilization, Hydrogen-Ion Concentration, Protons, Sea Urchins, Sodium, Zygote
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