The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Design and self-assembly of two-dimensional DNA crystals
Abstract
Molecular self-assembly presents a 'bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular interactions between the structural units are programmed by the design of 'sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.
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“Robust, rigid DNA tiles with programmable “sticky ends” have been made using double-crossover (DX),141 triple-crossover (TX),142 and single-stranded tile (SST)143 motifs and used for a variety of algorithmic self-assembly experiments.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [141]
Citations
Cites
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Self-citation
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1 of the 37 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Wang, H. in Proc. Symp. Math. Theory of Automata 23–56 (Polytechnic, New York, (1963)).
- Reif, J. in Proceedings of the 3rd DIMACS Meeting on DNA Based Computers, University of Pennsylvania, June 23–25, 1997 (American Mathematical Society, Providence, RI, in the press).
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Cited by
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Seeman, N. C. (2003) · Nature · doi:10.1038/nature01406 · Cited by 2,792
Self-citationSelf-assembly of DNA into nanoscale three-dimensional shapes
Douglas, S. M., Dietz, H., Liedl, T., Högberg, B., Graf, F., & Shih, W. M. (2009) · Nature · doi:10.1038/nature08016 · Cited by 2,617
A DNA-fuelled molecular machine made of DNA
Yurke, B., Turberfield, A. J., Mills, A. P., Simmel, F. C., & Neumann, J. L. (2000) · Nature · doi:10.1038/35020524 · Cited by 2,426
Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science
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Triggered amplification by hybridization chain reaction
Dirks, R. M., & Pierce, N. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407024101 · Cited by 2,095
Metadata
- Authors
- Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C.
- Affiliations
- California Institute of Technology (US)
- New York University (US)
- Corresponding author
- Winfree, Erik
- Venue
- Nature
- Published
- 1998-08
- Volume
- 394
- Issue
- 6693
- Pages
- 539-544
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1567090568
- Cited by
- 2,857
- References
- 37
- Citations by year
- 2026: 41 · 2025: 63 · 2024: 75 · 2023: 90 · 2022: 103 · 2021: 102 · 2020: 116 · 2019: 98 · 2018: 116 · 2017: 118 · 2016: 115 · 2015: 135 · 2014: 139 · 2013: 142 · 2012: 139
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Mathematics › Theoretical Computer Science › DNA and Biological Computing
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- DNA self-assembly, sticky ends, Watson-Crick complementarity, synthetic DNA, nanopatterning, periodic patterns, bottom-up nanofabrication
- MeSH terms
- Base Sequence, Crystallization, DNA, Electrophoresis, Polyacrylamide Gel, Molecular Sequence Data, Nucleic Acid Conformation, Surface Properties, Microscopy, Atomic Force
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