Oligodendrocyte abnormalities in shiverer mouse mutant are determined in primary chimaeras

There is increasing interest in hereditary dysmyelinating mutant mice such as jimpy, quaking, shiverer and twitcher, as animal models for leukodystrophy in man. These mutants are characterized by severe tremor and tonic convulsions. Shiverer is an autosomal recessive mutant which displays abnorma…