The DOI matches its Crossref record.
Rapid transport of foreign particles microinjected into crab axons
Abstract
The rapid transport of optically detectable organelles in axons has been well documented, although its molecular mechanism remains unknown. Here we report that synthetic particles microinjected into the giant axons of the shore crab, Carcinus maenas, are also transported, moving as though they were endogenous organelles. Polystyrene beads, polyacrolein beads, paraffin droplets and glass fragments, of sizes up to 0.5 micron in diameter, have been tested. Many of these foreign particles move rapidly and for long distances along the axon in the anterograde direction, travelling in a saltatory fashion, within a well defined velocity range. In many respects the movements are indistinguishable from those of anterogradely moving endogenous organelles seen by phase-contrast in these axons. Our results indicate that there is a transport system in axons capable of carrying almost any particle of suitable physical properties in an anterograde direction.
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“as is the movement of negatively charged beads injected into crab axons (Adams and Bray, 1983)”
From Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility (1985) · cites this paper as Adams and Bray, 1983
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Research works printed but not linked: 12
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Cited by
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Translocation of inhaled ultrafine particles to the brain
Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., & Cox, C. (2004) · Inhalation Toxicology · doi:10.1080/08958370490439597 · Cited by 2,606
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Metadata
- Authors
- Adams, R. J., & Bray, D.
- ORCID
- Adams, Richard J.
- Venue
- Nature
- Published
- 1983-06
- Volume
- 303
- Issue
- 5919
- Pages
- 718-720
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2005244767
- Cited by
- 93
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 1
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- axonal transport, anterograde transport, foreign particles, microinjection, giant axons, Carcinus maenas, polystyrene microspheres, organelle transport
- MeSH terms
- Acrolein, Animals, Axons, Axonal Transport, Brachyura, Foreign Bodies, Glass, Kinetics, Microinjections, Paraffin, Polymers, Polystyrenes
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
