CoChat
Sign Up
Cited by 388

The DOI matches its Crossref record.

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

Williams, David A., Lemischka, Ihor R., Nathan, David G., Mulligan, Richard C.·1984·Nature
DOI 10.1038/310476a0
Open this paper in CoChat — free account

Abstract

An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow tissue. Subsequent transplantation of the cells into lethally irradiated mice results in engraftment of the animals with donor haematopoietic tissue containing the bacterial gene. This approach affords an efficient and rapid means of re-introducing genetically modified tissue into intact organisms and provides a system whereby the expression and regulation of cloned genes can be followed within the context of a well characterized developmental programme.

Overview

Integrity signals

Registry

Crossref · 10.1038/310476a0

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 28

  1. Chao, M. V., Mellon, P., Charnay, P., Maniatis, T. & Axel, R. Cell 32, 483–493 (1983). · DOI
  2. Zinn, K., Mellon, P., Ptashne, M. & Maniatis, T. Proc. natn. Acad. Sci. U.S.A. 79, 4897–4901 (1982). · DOI
  3. Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. Cell 33, 717–728 (1983). · DOI
  4. Huang, A. L., Ostrowski, M. C., Berard, D. & Hager, G. L. Cell 27, 245–255 (1981). · DOI
  5. Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E. & Brinster, R. L. Science 222, 809–814 (1983). · DOI
  6. Cline, M. J. & Golde, D. W. Nature 277, 177–181 (1979). · DOI
  7. Nathan, D. G. & Oski, F. A. (eds) Hematology of Infancy and Childhood (Saunders, Philadelphia, 1981).
  8. Ferrero, D. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4114–4118 (1983). · DOI
  9. Johnson, G. R. J. cell. Physiol. 103, 371–383 (1980). · DOI
  10. McLeod, D. L., Shreeve, M. M. & Axelrad, A. A. Blood 44, 517–534 (1974). · DOI
  11. Till, J. E. & McCulloch, E. A. Radiat. Res. 14, 213–222 (1961). · DOI
  12. Lewis, J. P. & Trobaugh, F. E. Jr Nature 204, 589–590 (1964). · DOI
  13. Cline, M. J. et al. Nature 284, 422–425 (1980). · DOI
  14. Carr, F., Medina, W. D., Dube, S. & Bertino, J. R. Blood 62, 180–185 (1982). · DOI
  15. Mulligan, R. C. Experimental Manipulation of Gene Expression (ed. Inouye, M.) 155–173 (Academic, Orlando, Florida, 1983). · DOI
  16. Cepko, C. & Mulligan, R. C. Cell (in the press).
  17. Dexter, T. M., Allen, T. D. & Lajtha, L. G. J. cell. Physiol. 91, 335–344 (1976). · DOI
  18. Mauch, P., Greenberger, J. S., Botnick, L., Hannon, E. & Hellman, S. Proc. natn. Acad. Sci. U.S.A. 77, 2927–2930 (1980). · DOI
  19. Curry, J. L. & Trentin, J. J. Devl Biol. 15, 395–413 (1967). · DOI
  20. Magli, M. C., Iscove, N. N. & Odartchenko, N. Nature 245, 527–529 (1982). · DOI
  21. Mann, R., Mulligan, R. C. & Baltimore, D. Cell 33, 153–159 (1983). · DOI
  22. Van de Woude, G. F. et al. Cold Spring Harb. Symp. quant. Biol. 44, 735–745 (1979). · DOI
  23. Nunberg, J. H., Kaufman, R. J., Chang, A. C. Y., Cohen, S. N. & Sckimke, R. J. Cell 19, 355–364 (1980). · DOI
  24. Southern, P. J. & Berg, P. J. molec. appl. Genet. 1, 327–341 (1982).
  25. Southern, E. M. J. molec. Biol. 98, 503–517 (1975). · DOI
  26. Barnes, D. W. H., Evans, E. P., Ford, C. E. & West, B. J. Nature 219, 518–520 (1968). · DOI
  27. Wu, A. M., Till, J. E., Siminovitch, L. & McCulloch, E. A. J. cell. Physiol. 69, 177–184 (1967). · DOI
  28. Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237–251 (1977). · DOI

Cited by

Metadata

Authors
Williams, D. A., Lemischka, I. R., Nathan, D. G., & Mulligan, R. C.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1984-08
Volume
310
Issue
5977
Pages
476-480
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/310476a0
Cited by
388
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review