Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
Abstract
When stimulated with antigen, B cells are influenced by T cells to proliferate and differentiate into antibody-forming cells. Since it was reported that soluble factors could replace certain functions of helper T cells in the antibody response, several different kinds of lymphokines and monokines have been reported in B-cell growth and differentiation. Among these, human B-cell differentiation factor (BCDF or BSF-2) has been shown to induce the final maturation of B cells into immunoglobulin-secreting cells. BSF-2 was purified to homogeneity and its partial NH2-terminal amino-acid sequence was determined. These studies indicated that BSF-2 is functionally and structurally unlike other known proteins. Here, we report the molecular cloning, structural analysis and functional expression of the cDNA encoding human BSF-2. The primary sequence of BSF-2 deduced from the cDNA reveals that BSF-2 is a novel interleukin consisting of 184 amino acids.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-6 was originally identified as B-cell stimulating factor-2 (BSF-2), an inducer of immunoglobulin production.
“It was originally identified as B-cell stimulating factor-2 (BSF-2), an inducer of immunoglobulin production (27).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [27]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 23 · Cited by 2,139
- Authors
- Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y., Taniguchi, T., & Kishimoto, T.
- Affiliations
- The University of Osaka (JP)
- ORCID
- Venue
- Nature
- Published
- 1986-11
- Volume
- 324
- Issue
- 6092
- Pages
- 73-76
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2002076761
- Cited by
- 2,139
- References
- 23
- Citations by year
- 2026: 26 · 2025: 34 · 2024: 31 · 2023: 37 · 2022: 42 · 2021: 49 · 2020: 47 · 2019: 28 · 2018: 34 · 2017: 47 · 2016: 33 · 2015: 33 · 2014: 55 · 2013: 34 · 2012: 49
- FWCI
- 51.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- interleukins, B cell differentiation factor, B cell activation, antibody production, cDNA cloning, gene cloning, amino acid sequence, lymphokines, antibody response, T helper cells
- MeSH terms
- Amino Acid Sequence, Antibody-Producing Cells, B-Lymphocytes, Base Sequence, Cell Differentiation, DNA, Growth Substances, Humans, Immunoglobulins, Lymphokines, Interleukin-4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
