Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
Abstract
A domain in the low-density lipoprotein receptor contains three cysteine-rich 'growth factor' repeats like those that occur in many proteins. When this domain is deleted, the receptor no longer releases its ligand at acid pH, it is no longer recycled efficiently and it is rapidly degraded after ligand binding.
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LRAD3 lacks the EGF and β-propeller domains found in extracellular portions of LDL receptor family members.
“LRAD3 also lacks the EGF and β-propeller domains that are found in the extracellular portions of LDL receptor family members which are important for pH-induced uncoupling of ligands within acidic endosomal compartments (Davis et al., 1987; Mikhailenko et al., 1999; Rudenko et al., 2002).”
From LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking (2011) · cites this paper as Davis et al., 1987
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References 28 · Cited by 411
- Authors
- Davis, C. G., Goldstein, J. L., Südhof, T. C., Anderson, R. G. W., Russell, D. W., & Brown, M. S.
- Affiliations
- University of Texas Health Science Center at Dallas (US)
- Venue
- Nature
- Published
- 1987-04-01
- Volume
- 326
- Issue
- 6115
- Pages
- 760-765
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2059813073
- Cited by
- 411
- References
- 28
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 5 · 2018: 11 · 2017: 11 · 2016: 6 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 5
- FWCI
- 38.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- LDL receptor, cysteine-rich repeats, ligand dissociation, low pH, receptor recycling, receptor degradation, ligand binding
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Chromosome Deletion, Cricetulus, Cysteine, Epidermal Growth Factor, Cricetinae, Hydrogen-Ion Concentration, Lipoproteins, LDL, Lipoproteins, VLDL, Plasmids, Protein Precursors, Receptors, LDL, Repetitive Sequences, Nucleic Acid, Structure-Activity Relationship
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