The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds)
Open accessAbstract
MUTANT mice homozygous for 'retinal degeneration slow' (rds/rds) are characterized phenotypically by abnormal development of photoreceptor outer segments in the retina, followed by gradual degeneration of photoreceptors1–3. This process of degeneration is complete by one year, with preservation of all other retinal cells4. The biochemical defect that leads to the mutant phenotype is not known. Our strategy for cloning the rds gene was based upon three previously reported observations. First, the rds locus maps to chromosome 175,6. Second, experimental rds/rds ↦+/+ and rds/+ ↦ +/+ tetra-parental mice manifest patchy photoreceptor changes in the retina7,8 suggesting that the wild-type rds locus is expressed within cells of the photoreceptor lineage. Finally, the process of degeneration is specific to photore-ceptors. On the basis of these observations, we predicted that the rds mRNA is encoded by a gene on chromosome 17 and is normally expressed exclusively within photoreceptors in the retina. We here present evidence that this is the case.
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Citations
Cites
A New H‐2‐Linked Mutation, rds , Causing Retinal Degeneration in the Mouse
van Nie, R., Iványi, D., & Démant, P. (1978) · Tissue Antigens · doi:10.1111/j.1399-0039.1978.tb01305.x · Cited by 191
Cited by
Wells, J., Wroblewski, J., Keen, J., Inglehearn, C., Jubb, C., Eckstein, A., Jay, M., Arden, G., Bhattacharya, S., Fitzke, F., et al. (1993) · Nature Genetics · doi:10.1038/ng0393-213 · Cited by 438
Rosenfeld, P. J., Cowley, G. S., McGee, T. L., Sandberg, M. A., Berson, E. L., & Dryja, T. P. (1992) · Nature Genetics · doi:10.1038/ng0692-209 · Cited by 422
Cloning of a gene that is rearranged in patients with choroideraemia
Cremers, F. P. M., van de Pol, D. J. R., van Kerkhoff, L. P. M., Wieringa, B., & Ropers, H.-H. (1990) · Nature · doi:10.1038/347674a0 · Cited by 333
Chang, B., Khanna, H., Hawes, N., Jimeno, D., He, S., Lillo, C., Parapuram, S. K., Cheng, H., Scott, A., Hurd, R. E., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl107 · Cited by 328
Retinitis pigmentosa and allied diseases: numerous diseases, genes, and inheritance patterns
Rivolta, C. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.10.1219 · Cited by 296
Metadata
- Authors
- Travis, G. H., Brennan, M. B., Danielson, P. E., Kozak, C. A., & Sutcliffe, J. G.
- Venue
- Nature
- Published
- 1989-03
- Volume
- 338
- Issue
- 6210
- Pages
- 70-73
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2088449181
- Cited by
- 400
- References
- 1
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Travis, G. H., Brennan, M. B., Danielson, P. E., Kozak, C. A., & Sutcliffe, J. G. (1989). Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds). Nature. https://doi.org/10.1038/338070a0
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