The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor
Abstract
The vitamin A derivative, retinoic acid, can regulate morphogenesis and differentiation in vertebrates. Two different subfamilies of the steroid receptor superfamily of transcription factors, the retinoic acid receptors and the retinoid X receptor, mediate the effects of retinoic acid. As part of an analysis of the hormonal control of development, we have examined the Drosophila genome for retinoic acid receptor homologues. Here we describe one such gene, XR2C, which encodes a product with structural similarity to the human retinoic acid-responsive transcription factor, retinoid X receptor. This receptor-like protein is encoded by ultraspiracle (usp), a locus required both maternally and zygotically for pattern formation. The discovery that the usp product is a retinoid X receptor homologue suggests that similar chemical cues underlie morphogenic signalling in vertebrate and invertebrate systems.
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In the citing paper
“EcR must interact with the ultraspiracle protein (USP), retinoid X receptor (RXR) in Hemimetabola, the ortholog of the retinoid X receptor in vertebrates, to form a heterodimeric transcription complex, EcR/USP [37].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [37]
In the citing paper
“Nuclear receptors act by forming homodimers or heterodimers. For example, the glucocorticoid receptor [1] and estrogen receptor [2] form a homodimer, and insect ecdysone receptor (EcR) forms a heterodimer with an ultraspiracle protein (USP), the ortholog of retinoid X receptor in vertebrates [3].”
From G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane (2014) · cites this paper as [3]
Citations
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Cited by
Sorted by citations
Yu, V. C. K., Delsert, C., D, B. A. M., Holloway, J. M., Devary, O. V., Näär, A. M., Kim, S. Y., Boutin, J., Glass, C. K., & Rosenfeld, M. G. (1991) · Cell · doi:10.1016/0092-8674(91)90301-e · Cited by 1,188
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.Preprint
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Self-citationNuclear Receptors, RXR, and the Big Bang
Evans, R. M., & Mangelsdorf, D. J. (2014) · Cell · doi:10.1016/j.cell.2014.03.012 · Cited by 1,200
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Metadata
- Authors
- Oro, A. E., McKeown, M., & Evans, R. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Salk Institute for Biological Studies (US)
- Venue
- Nature
- Published
- 1990-09
- Volume
- 347
- Issue
- 6290
- Pages
- 298-301
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1966843280
- Cited by
- 406
- References
- 22
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 2 · 2018: 8 · 2017: 5 · 2016: 1 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 10
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- ultraspiracle, retinoid X receptor, retinoic acid receptor, retinoic acid, steroid receptor superfamily, transcription factors, Drosophila, vertebrate-invertebrate comparison, morphogenesis, pattern formation, gene homology
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Carrier Proteins, DNA, Drosophila, Humans, Molecular Sequence Data, Mutation, Nucleic Acid Hybridization, Sequence Homology, Nucleic Acid, Restriction Mapping, Receptors, Retinoic Acid
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