Faster superoxide dismutase mutants designed by enhancing electrostatic guidance

Getzoff, Elizabeth D., Cabelli, Diane E., Fisher, Cindy L., Parge, Hans E., Viezzoli, Maria Silvia, Banci, Lucia, Hallewell, Robert A.·1992·Nature
DOI 10.1038/358347a0

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  2. Strategies of Antioxidant Defense: Relations to Oxidative Stress
    Helmut Sies · 1995 · Springer eBooks
  3. Selective Inhibition of Fe- versus Cu/Zn-Superoxide Dismutases by 2,3-Dihydroxybenzoic Acid Derivatives.
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  4. Simulation of Bimolecular Reactions
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  12. Electrostatic effects in trypsin reactions
    Vello Tõugu, Toomas Tiivel, Peeter Talts, Virginius Šikšnis, S. A. Poyarkova, Tönu Kesvatera, Aavo Aaviksaar · 1994 · European Journal of Biochemistry
  13. Copper‐Zinc Superoxide Dismutase in Prokaryotes and Eukaryotes
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  14. Superperfect enzymes
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  18. Evaluation of the kinetics of electrostatically steered protein dimerization using Weighted-Ensemble Brownian dynamics
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  19. Responses of Superoxide Dismutases to Oxidative Stress in Arabidopsis thaliana
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  21. Amyotrophic Lateral Sclerosis
    David S., J. Ashley, D. Elizabeth, J. Jefferson P. Perry · 2011 · InTech eBooks
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  25. Development of In Silico Analysis and Molecular Dynamics Simulation on L67P and D76Y Mutants of the Human Superoxide Dismutase 1(hSOD1) Related to Amyotrophic Lateral Sclerosis.
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  26. DIRECTED EVOLUTION OF CYANIDE DEGRADING ENZYMES
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  28. On the molecular spin density and the electrostatic potential as determinants of the relaxivity of metalloporphyrins
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    Tom L. Blundell, Roderick E. Hubbard, Michael Aaron Weiss · 1992 · Diabetologia
  31. Copper‐cobalt superoxide dismutase: A re‐examination of the 1H NMR spectrum through a novel selectively deuteriated derivative
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  34. Copper-Zinc Superoxide Dismutase: Mechanistic and Biological Studies
    Joan Selverstone Valentine, Lisa Ellerby, Janet A. Graden, Clinton R. Nishida, Edith Butler Gralla · 1995 · Springer eBooks
  35. Kinetic effects of mutations of charged residues on the surface of a dimeric hemoglobin: insights from Brownian dynamics simulations
    Eric W. Fisher, Atipat Rojnuckarin, Sangtae Kim · 2001 · Journal of Molecular Structure THEOCHEM
  36. Future directions for combining molecular and continuum models in protein simulations
    Gary Huber · 1998 · Progress in Biophysics and Molecular Biology
  37. Proton ENDOR spectroscopy of cyanide-inhibited copper-zinc superoxide dismutase in randomly oriented samples
    Hans-Josef Scholl, Jürgen Hüttermann, Maria-Silvia Viezzoli · 1998 · Inorganica Chimica Acta
  38. Reactive Oxygen Species
    Virender K. Sharma · 2012 · Wiley eBooks
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    Ming‐Hong Hao, Stephen C. Harvey · 1995 · Biochimica et Biophysica Acta (BBA) - Biomembranes
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  52. Simulation of enzyme-substrate interactions: the diffusional encounter step.
    Rebecca C. Wade · 1995 · Acta Biochimica Polonica
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    David E. Metzler, Carol M. Metzler, David J. Sauke · 2001 · Elsevier eBooks
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  59. Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS
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  60. Copper‐Zinc Superoxide Dismutase in Prokaryotes and Eukaryotes
    Domenico Bordo, Alessandra Pesce, Martino Bolognesi, Maria Elena Stroppolo, Mattia Falconi, Alessandro Desideri · 2004 · Wiley eBooks
  61. Food enzymes
    Sibel D. Roller, Peter W. Goodenough · 1998 · Springer eBooks
  62. B rownian Dynamics
    Jeffry D. Madura, James M. Briggs, Rebecca C. Wade, Razif R. Gabdoulline · 1998 · Encyclopedia of Computational Chemistry
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    Roberth Byström · 2009 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  64. Molecular Dynamics Calculations on Metalloproteins
    Lucia Banci, Giovanni Gori Savellini · 1997 · Springer eBooks
  65. Computational Strategies for Modeling Receptor Flexibility in Studies of Receptor-Ligand Interactions
    Rebecca C. Wade, Susanna K. Lüdemann · 1998 · Springer eBooks
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    Tana Jubany-Marí · 2009 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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    Marsha Jane Lewis · 2010
  68. Perplexing Protein Puzzles
    Stina Lindman · 2010 · Lund University Publications (Lund University)
  69. Nickelhaltige Enzyme: Die steile Karriere eines lange übersehenen Biometalls
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  71. Kupferhaltige Proteine: Die Alternative zu biologischem Eisen
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  72. ANALYSIS OF SELECTION ON
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  81. CHAPTER SYMBIOSIS
    T. A. Sarma · 2012 · CRC Press eBooks
  82. Bibliography
    2009 · Wiley eBooks
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    Payam Baziyar, Bagher Seyedalipour, Saman Hosseinkhani · 2022 · SSRN Electronic Journal
  84. Nickelhaltige Enzyme: Die steile Karriere eines lange übersehenen Biometalls
    Wolfgang Kaim, Brigitte E. Schwederski · 1995 · Teubner-Studienbücher. Chemie
  85. Kupferhaltige Proteine: Die Alternative zu biologischem Eisen
    Wolfgang Kaim, Brigitte E. Schwederski · 2005 · Teubner-Studienbücher. Chemie
  86. Kupferhaltige Proteine: Die Alternative zu biologischem Eisen
    Wolfgang Kaim, Brigitte E. Schwederski · 2004 · Teubner-Studienbücher. Chemie
  87. Notizen
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  88. References
    2010 · Elsevier eBooks
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  99. Basic conformers in ?-peptides
    1999