Cited by 2,864Cancer-related Molecular PathwaysCell death mechanisms and regulationT-cell and B-cell Immunology

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p53 is required for radiation-induced apoptosis in mouse thymocytes

Lowe, Scott W., Schmitt, Earlene M., Smith, Sallie W., Osborne, Barbara A., Jacks, Tyler·1993·Nature

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Abstract

The p53 tumour suppressor gene is the most widely mutated gene in human tumorigenesis. p53 encodes a transcriptional activator whose targets may include genes that regulate genomic stability, the cellular response to DNA damage, and cell-cycle progression. Introduction of wild-type p53 into cell lines that have lost endogenous p53 function can cause growth arrest or induce a process of cell death known as apoptosis. During normal development, self-reactive thymocytes undergo negative selection by apoptosis, which can also be induced in immature thymocytes by other stimuli, including exposure to glucocorticoids and ionizing radiation. Although normal negative selection involves signalling through the T-cell receptor, the induction of apoptosis by other stimuli is poorly understood. We have investigated the requirement for p53 during apoptosis in mouse thymocytes. We report here that immature thymocytes lacking p53 die normally when exposed to compounds that may mimic T-cell receptor engagement and to glucocorticoids but are resistant to the lethal effects of ionizing radiation. These results demonstrate that p53 is required for radiation-induced cell death in the thymus but is not necessary for all forms of apoptosis.

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Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Antibodies: A laboratory manual
J.L. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90307-1 · Cited by 5,141
p53, guardian of the genome
Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
Wyllie, A. H. (1980) · Nature · doi:10.1038/284555a0 · Cited by 4,499
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Self-citation
Handbook of Experimental Immunology.
Denman, A. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-68-6-1376_1 · Cited by 2,414

Show all 44 references

Research works printed but not linked: 1

Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. & Craig, R. W. Cancer Res. 51, 6304–6311 (1991).

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Godley, L. A., Kopp, J. B., Eckhaus, M., Paglino, J. J., Owens, J., & VARMUS, H. E. (1996) · Genes & Development · doi:10.1101/gad.10.7.836 · Cited by 120
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Roy, B., Beamon, J., Bálint, É., & Reisman, D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7805 · Cited by 120
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Leri, A., Liu, Y., Malhotra, A., Li, Q., Stiegler, P., Claudio, P. P., Giordano, A., Kajstura, J., Hintze, T. H., & Anversa, P. (1998) · Circulation · doi:10.1161/01.cir.97.2.194 · Cited by 118
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DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts
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DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling
Tee, A. R., & Proud, C. G. (2000) · Oncogene · doi:10.1038/sj.onc.1203622 · Cited by 119
ei24 , a p53 Response Gene Involved in Growth Suppression and Apoptosis
Gu, Z., Flemington, C., Chittenden, T., & Zambetti, G. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.233-241.2000 · Cited by 118
Potential molecular targets for manipulating the radiation response
Maity, A. M., Kao, G. D., Muschel, R. J., & McKenna, W. G. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00598-6 · Cited by 117
Apoptosis and its role in the myelodysplastic syndromes: implications for disease natural history and treatment
Greenberg, P. L. (1998) · Leukemia Research · doi:10.1016/s0145-2126(98)00112-x · Cited by 117
Participation of the human p53 3′UTR in translational repression and activation following γ‐irradiation
Fu, L., & Benchimol, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.4117 · Cited by 116
Isolation of DAP3, a Novel Mediator of Interferon-γ-induced Cell Death
Kissil, J. L., Deiss, L. P., Bayewitch, M. L., Raveh, T., Khaspekov, G. L., & Kimchi, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27932 · Cited by 116
Involvement of p53 in DNA Strand Break‐induced Apoptosis in Postmitotic CNS Neurons
Enokido, Y., Araki, T., Tanaka, K., Aizawa, S., & Hatanaka, H. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01325.x · Cited by 117
The role of TP53 in acute myeloid leukemia: Challenges and opportunities
Barbosa, K., Li, S., Adams, P. D., & Deshpande, A. J. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22796 · Cited by 118
Thep53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers
Hamada, M., Fujiwara, T., HIZUTA, A., Gochi, A., Naomoto, Y., Takakura, N., Takahashi, K., Roth, J. A., Tanaka, N., & Orita, K. (1996) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01220804 · Cited by 115
Functional genomics in mice by tagged sequence mutagenesis
Hicks, G. G., Shi, E., Li, X.-M., Li, C., Pawlak, M., & Ruley, H. E. (1997) · Nature Genetics · doi:10.1038/ng0897-338 · Cited by 115
Apoptosis in the developing CNS
Naruse, I., & Keino, H. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00024-p · Cited by 115
Death squads enlisted by the tumour suppressor p53
Michalak, E. M., Villunger, A., Erlacher, M., & Strasser, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.183 · Cited by 116
p53 and the Li-Fraumeni syndrome
Malkin, D. M. (1994) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(94)90014-0 · Cited by 116
Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity.
Gallardo, D., Drazan, K. E., & McBride, W. H. (1996) · PubMed · Cited by 114
Heat Shock Protein 84 Forms a Complex with Mutant p53 Protein Predominantly within a Cytoplasmic Compartment of the Cell
Sepehrnia, B., Paz, I. B., Dasgupta, G., & Momand, J. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15084 · Cited by 115
Regulation of the p53 protein by the MDM2 oncoprotein--thirty-eighth G.H.A. Clowes Memorial Award Lecture.
Freedman, D. A., & Levine, A. J. (1999) · PubMed · Cited by 114
Zinc deficiency and neurodevelopment: The case of neurons
Adamo, A. M., & Oteiza, P. I. (2010) · BioFactors · doi:10.1002/biof.91 · Cited by 118
Induction of Apoptosis in Neuroendocrine Tumors of the Digestive System During Treatment with Somatostatin Analogs
Imam, H., Eriksson, B. K., Lukinius, A., Janson, E. T., Lindgren, P.-G., Wilander, E., & Öberg, K. (1997) · Acta Oncologica · doi:10.3109/02841869709001323 · Cited by 113
Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage
Vanasse, G. J., CONCANNON, P. J., & Willerford, D. M. (1999) · Blood · doi:10.1182/blood.v94.12.3997 · Cited by 114
Tumor necrosis factor-alpha sensitizes prostate cancer cells to gamma-irradiation-induced apoptosis.
Kimura, K., Bowen, C., Spiegel, S., & Gelmann, E. P. (1999) · PubMed · Cited by 112
Proapoptotic BAX and BAK control multiple initiator caspases
Ruiz‐Vela, A., Opferman, J. T., Cheng, E. H. Y., & Korsmeyer, S. J. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400375 · Cited by 112
Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice.
LaFerla, F. M., Hall, C. K., Ngo, L. T., & Jay, G. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118957 · Cited by 112
Bcl-2 Family Members as Sentinels of Cellular Integrity and Role of Mitochondrial Intermembrane Space Proteins in Apoptotic Cell Death
Festjens, N., van Gurp, M., Loo, G., Saelens, X., & Vandenabeele, P. (2003) · Acta Haematologica · doi:10.1159/000074483 · Cited by 115
Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix
Nakagawa, S., Yano, T., Nakagawa, K., Takizawa, S., Suzuki, Y., Yasugi, T., Huibregtse, J. M., & Taketani, Y. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601465 · Cited by 117
The high risk human papillomaviruses and oral cancer: evidence for and against a causal relationship
Sugerman, P. B., & Ej, S. (1997) · Oral Diseases · doi:10.1111/j.1601-0825.1997.tb00025.x · Cited by 112
Cell Death Induced by Baicalein in Human Hepatocellular Carcinoma Cell Lines
Matsuzaki, Y., Kurokawa, N., Terai, S., Matsumura, Y., Kobayashi, N., & Okita, K. (1996) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1996.tb03155.x · Cited by 112
Rescue of T Cell-Specific V(D)J Recombination in SCID Mice by DNA-Damaging Agents
Danska, J. S., Pflumio, F., Williams, C. J., Huner, O., Dick, J. E., & Guidos, C. J. (1994) · Science · doi:10.1126/science.7524150 · Cited by 112
Estrogen-Induced Apoptosis by Inhibition of the Erythroid Transcription Factor GATA-1
Blobel, G. A., & Orkin, S. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1687 · Cited by 114
Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.
Borner, M., Myers, C. E., Sartor, O. A., Sei, Y., Toko, T., Trepel, J. B., & Schneider, E. (1995) · PubMed · Cited by 112
Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage
Hsieh, J.-K., Yap, D., O’Connor, D. J., Fogal, V., Fallis, L., Chan, F., Zhong, S., & Lü, X. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.78-93.2002 · Cited by 112
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Roth, P., Wick, W., & Weller, M. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32833e5a5d · Cited by 115
Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus.
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p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
Koldobskiy, M. A., Chakraborty, A., Werner, J. K., Snowman, A. M., Juluri, K. R., Vandiver, M. S., Kim, S., Heletz, S., & Snyder, S. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015671107 · Cited by 112
Chicken anaemia virus infection: Molecular basis of pathogenicity
Noteborn, M. H. M., & Koch, G. (1995) · Avian Pathology · doi:10.1080/03079459508419046 · Cited by 110
Apoptosis — Molecular mechanisms and biomedical implications
McConkey, D. J., Zhivotovsky, B., & Orrenius, S. (1996) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(95)00006-2 · Cited by 110
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Hughes, P. E., Alexi, T., Yoshida, T., Schreiber, S. S., & Knüsel, B. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00174-1 · Cited by 110
Apoptosis and cancer chemotherapy
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Nrf2 promotes survival following exposure to ionizing radiation
Sekhar, K. R., & Freeman, M. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.035 · Cited by 109
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Komarova, E. A., Neznanov, N., Komarov, P. G., Chernov, M. V., Wang, K., & Gudkov, A. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300011200 · Cited by 109
Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice.
Li, G., Mitchell, D. L., Ho, V. C., Reed, J. C., & Tron, V. A. (1996) · Europe PMC (PubMed Central) · Cited by 109
The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21 BAX expression
Shu, H. G., Kim, M. M., Chen, P., Furman, F., Julin, C. M., & Israel, M. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14453 · Cited by 109
Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest
Wu, G. S., Burns, T. F., McDonald, E. R., Meng, R. D., Kao, G. D., Muschel, R. J., Yen, T. J., & El‐Deiry, W. S. (1999) · Oncogene · doi:10.1038/sj.onc.1203025 · Cited by 109
Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency
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p21 delays tumor onset by preservation of chromosomal stability
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Bae, I. S., Fan, S., Bhatia, K. G., Kohn, K. W., Fornace, A. J., & O'Connor, P. M. (1995) · PubMed · Cited by 108
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Li, W., Fan, J., Hochhauser, D., Banerjee, D., Zieliński, Z., Almasan, A., Yin, Y., Kelly, R., Wahl, G. M., & Bertino, J. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10436 · Cited by 108
Modulation of tumor cell gene expression and phenotype by the organspecific metastatic environment
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Ghaleb, A. M., Katz, J. P., Kaestner, K. H., Du, J. X., & Yang, V. W. (2006) · Oncogene · doi:10.1038/sj.onc.1210022 · Cited by 107
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Wang, Z., & Templeton, D. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.73 · Cited by 107
Anti‐apoptotic activity of low levels of wild‐type p53.
Lassus, P., Ferlin, M., Piette, J., & Hibner, U. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00834.x · Cited by 108
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis
Rudner, J., Lepple‐Wienhues, A., Budach, W., Berschauer, J. E., Friedrich, B., Wesselborg, S., Schulze‐Osthoff, K., & Belka, C. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.23.4161 · Cited by 107
Epstein‐Barr virus efficiently immortalizes human B cells without neutralizing the function of p53.
Allday, M. J., Sinclair, A. J., Parker, G. A., Crawford, D., & Farrell, P. J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07124.x · Cited by 107
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The DNA of annexin V-binding apoptotic cells is highly fragmented.
Bacsó, Z., Everson, R. B., & Eliason, J. F. (2000) · PubMed · Cited by 106
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers
Zhao, R., Yeung, S. J., Chen, J., Iwakuma, T., Su, C., Chen, B., Qu, C., Zhang, F., Chen, Y., Lin, Y., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44111 · Cited by 107
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Canman, C. E., & Kastan, M. B. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61068-6 · Cited by 106
Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells.
Katayose, D., Gudas, J. M., Nguyen, H., Srivastava, S., Cowan, K. H., & Seth, P. K. (1995) · PubMed · Cited by 106
Cell cycle regulation in response to DNA damage in mammalian cells: A historical perspective
Murnane, J. P. (1995) · Cancer and Metastasis Reviews · doi:10.1007/bf00690208 · Cited by 106
p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.
Jiang, D., Lenardo, M. J., & Zúñiga‐Pflücker, J. C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1923 · Cited by 105
Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage
Solozobova, V., Rolletschek, A., & Blattner, C. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-46 · Cited by 107
Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish
Langenau, D. M., Jette, C. A., Berghmans, S., Palomero, T., Kanki, J. P., Kutok, J. L., & Look, A. T. (2004) · Blood · doi:10.1182/blood-2004-08-3073 · Cited by 107
Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-κBp65 expression in breast cancer MDA-MB-231 cells
Su (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000153 · Cited by 105
The Spectrum of Mutations at the p53 Locus
Levine, A. J., Wu, M. C., Chang, A., Silver, A., Attiyeh, E. F., Lin, J., & Epstein, C. B. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb12115.x · Cited by 106
Accumulation of wild‐type p53 protein upon gamma‐irradiation induces a G2 arrest‐dependent immunoglobulin kappa light chain gene expression.
Aloni-Grinstein, R., Schwartz, D., & Rotter, V. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07125.x · Cited by 105
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Salomoni, P., Ferguson, B. J., Wyllie, A., & Rich, T. (2008) · Cell Research · doi:10.1038/cr.2008.58 · Cited by 107
TUMOR SUPPRESSOR GENE MUTATIONS IN MICE
Jacks, T. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.603 · Cited by 105
Self-citation
neu/ERBB2 Cooperates with p53-172H during Mammary Tumorigenesis in Transgenic Mice
Li, B., Rosen, J. M., McMenamin-Balano, J., Muller, W. J., & Perkins, A. S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3155 · Cited by 104
Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions
Chirmule, N. B., & Pahwa, S. G. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.2.386-406.1996 · Cited by 104
Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53.
McCarthy, S. A., Symonds, H., & Dyke, T. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3979 · Cited by 104
Transglutaminase induction by various cell death and apoptosis pathways
Fésüs, L., Mádi, A., Balajthy, Z., Nemes, Z., & Szondy, Z. (1996) · Cellular and Molecular Life Sciences · doi:10.1007/bf01920102 · Cited by 104
Mutation of Mouse p53 Ser23 and the Response to DNA Damage
Wu, Z., Earle, J., Saito, S., Anderson, C. W., Appella, E., & Xu, Y. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2441-2449.2002 · Cited by 103
Anti-apoptotic Bcl-2 proteins: structure, function and relevance for radiation biology
Belka, C., & Budach, W. (2002) · International Journal of Radiation Biology · doi:10.1080/09553000210137680 · Cited by 105
The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury
Napieralski, J. A., Raghupathi, R., & McIntosh, T. K. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00155-2 · Cited by 103
Increased p53 activity does not accelerate telomere‐driven ageing
García‐Cao, I., García‐Cao, M., Tomás‐Loba, A., Martin‐Caballero, J., Flores, J. M., Klatt, P., Blasco, M. A., & Serrano, M. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400667 · Cited by 102
Recent Trends in Covalent and Metal Organic Frameworks for Biomedical Applications
Chedid, G., & Yassin, A. (2018) · Nanomaterials · doi:10.3390/nano8110916 · Cited by 105
Functional genomics as a window on radiation stress signaling
Amundson, S. A., Bittner, M. L., & Fornace, A. J. (2003) · Oncogene · doi:10.1038/sj.onc.1206681 · Cited by 102

Authors: Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T.
Affiliations: Massachusetts Institute of Technology (US)
University of Massachusetts Amherst (US)
ORCID: Lowe, Scott W.
Osborne, Barbara A.
Jacks, Tyler
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1993-04
Volume: 362
Issue: 6423
Pages: 847-849
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/362847a0
OpenAlex: W2078581194
Cited by: 2,864
References: 44
Citations by year: 2026: 8 · 2025: 15 · 2024: 28 · 2023: 18 · 2022: 9 · 2021: 24 · 2020: 19 · 2019: 23 · 2018: 31 · 2017: 28 · 2016: 34 · 2015: 24 · 2014: 30 · 2013: 37 · 2012: 40
FWCI: 123.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: p53, radiation-induced apoptosis, thymocytes, ionizing radiation, negative selection, T cell receptor signaling, glucocorticoids, T cell development, tumor suppressor, radioresistance (biology)
MeSH terms: Animals, Cells, Cultured, Dexamethasone, Gamma Rays, Mice, Inbred C57BL, Mutation, Thymus Gland, Genes, p53, Tumor Suppressor Protein p53, Apoptosis, Mice

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p53 is required for radiation-induced apoptosis in mouse thymocytes

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