A common plan for dorsoventral patterning in Bilateria
Abstract
Functional studies seem now to confirm, as first suggested by E. Geoffroy Saint-Hilaire in 1822, that there was an inversion of the dorsoventral axis during animal evolution. A conserved system of extracellular signals provides positional information for the allocation of embryonic cells to specific tissue types both in Drosophila and vertebrates; the ventral region of Drosophila is homologous to the dorsal side of the vertebrate. Developmental studies are now revealing some of the characteristics of the ancestral animal that gave rise to the arthropod and mammalian lineages, for which we propose the name Urbilateria.
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References 55 · Cited by 780
- Authors
- De Robertis, E. M., & Sasai, Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Nature
- Published
- 1996-03
- Volume
- 380
- Issue
- 6569
- Pages
- 37-40
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1998342476
- Cited by
- 780
- References
- 55
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 12 · 2023: 12 · 2022: 14 · 2021: 11 · 2020: 9 · 2019: 22 · 2018: 14 · 2017: 19 · 2016: 28 · 2015: 23 · 2014: 16 · 2013: 13 · 2012: 21
- FWCI
- 19.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- dorsoventral patterning, Urbilateria, positional information, extracellular signaling, Drosophila, vertebrates, arthropods, mammalian evolution
- MeSH terms
- Animals, Drosophila, Embryo, Mammalian, Embryo, Nonmammalian, Embryonic Induction, Biological Evolution, Glycoproteins, Insect Hormones, Proteins, Xenopus, Bone Morphogenetic Proteins, Drosophila Proteins, Intercellular Signaling Peptides and Proteins
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