Role of intercellular interactions in heterosynaptic long-term depression
Abstract
Bidirectional control of synaptic strength is thought to be important for the development of neuronal circuits and information storage. The demonstration of homosynaptic long-term depression greatly enhances the usefulness of the synapse as a mnemonic device, but theoreticians have also seen the need for heterosynaptic decreases in synaptic efficacy, both in neuronal development and information storage. Indeed, induction of long-term potentiation in one population of synapses can be associated with a modest depression at neighbouring inactive synapses in the same population of cells. Here we report that in the CA1 region of the hippocampus this heterosynaptic long-term depression has the property that its sites of induction and expression occur in different populations of cells and thus requires the spread of a signal between neurons. Such a mechanism ensures a widespread distribution of this form of plasticity.
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LTP is often accompanied by a depression in neighboring nontetanized synapses, which would tend to renormalize excitatory drive onto the neuron.
“First, it has been reported that LTP is often accompanied by a depression in neighboring nontetanized synapses (372, 373), which would tend to renormalize excitatory drive onto the neuron.”
From Synaptic memory and CaMKII (2023) · cites this paper as [373]
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References 27 · Cited by 119
- Authors
- Scanziani, M., Malenka, R. C., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Nature
- Published
- 1996-04
- Volume
- 380
- Issue
- 6573
- Pages
- 446-450
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1974244318
- Cited by
- 119
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 5 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- intercellular communication, synaptic plasticity, homosynaptic plasticity, hippocampal CA1, long-term potentiation, neuronal development, information storage
- MeSH terms
- Animals, Cell Communication, Egtazic Acid, Hippocampus, Membrane Potentials, Synaptic Transmission, Neurons, Synapses, Calcium Channels, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Long-Term Potentiation, Rats, In Vitro Techniques
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