Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
Abstract
Signal transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines, and are thought to mediate many of their functional responses. Stat6 is activated in response to interleukin (IL)-4 and may contribute to various functions including mitogenesis, T-helper cell differentiation and immunoglobulin isotype switching. To evaluate the role of Stat6, we generated Stat6-null mice (Stat6 -/-) by gene disruption in embryonic stem cells. The mice were viable, indicating the lack of a non-redundant function in normal development. Although naive lymphoid cell development was normal, Stat6 -/- mice were deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, and immunoglobulin class switching to IgE. In contrast, IL-4-mediated proliferation was only partly affected.
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All of the other STAT knock-outs have relatively mild phenotypes correlated with rather specific defects in response to certain cytokines or growth factors.
“All of the other STAT knock-outs have relatively mild phenotypes correlated with rather specific defects in response to certain cytokines or growth factors (12”
From STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration (2002) · cites this paper as [37]
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References 28 · Cited by 1,278
- Authors
- Shimoda, K., van Deursent, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A. A., Doherty, P. C., Grosveld, G., Paul, W. E., & Ihle, J. N.
- Affiliations
- St. Jude Children's Research Hospital (US)
- National Institutes of Health (US)
- ORCID
- Venue
- Nature
- Published
- 1996-04-18
- Volume
- 380
- Issue
- 6575
- Pages
- 630-633
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2002186586
- Cited by
- 1,278
- References
- 28
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 14 · 2023: 20 · 2022: 17 · 2021: 11 · 2020: 21 · 2019: 19 · 2018: 14 · 2017: 20 · 2016: 19 · 2015: 21 · 2014: 23 · 2013: 28 · 2012: 24
- FWCI
- 45.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- STAT6, IL-4, IgE class switching, immunoglobulin isotype switching, gene disruption, T helper cell differentiation, lymphoid development, signal transducer and activator of transcription
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Cell Line, Cells, Cultured, Immunoglobulin E, Immunity, Lymphoid Tissue, Molecular Sequence Data, DNA Probes, Trans-Activators, Interleukin-4, Immunoglobulin Class Switching, Gene Targeting, Th2 Cells, STAT6 Transcription Factor, Mice
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