An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
Abstract
Amyloid-beta is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB immunoprecipitates with amyloid-beta, and when cell cultures are exposed to amyloid-beta, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-beta on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-beta, ERAB may therefore contribute to the neuronal dysfunction associated with Alzheimer's disease.
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Neuroprotective activities of Withania somnifera are well documented by many studies.
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From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [393]
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References 48 · Cited by 379
- Authors
- Du Yan, S., Fu, J., Soto, C., Chen, X., Zhu, H., Al-Mohanna, F., Collison, K., Zhu, A., Stern, E., Saido, T., Tohyama, M., Ogawa, S., Roher, A., & Stern, D.
- Affiliations
- Columbia University (US)
- NYU Langone Health (US)
- King Faisal Specialist Hospital & Research Centre (SA)
- Tokyo Metropolitan Institute of Medical Science (JP)
- The University of Osaka (JP)
- Banner Sun Health Research Institute (US)
- Venue
- Nature
- Published
- 1997-10
- Volume
- 389
- Issue
- 6652
- Pages
- 689-695
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2117037463
- Cited by
- 379
- References
- 48
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 7 · 2021: 3 · 2020: 13 · 2019: 10 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 9 · 2014: 10 · 2013: 7 · 2012: 12
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- ERAB: The European Foundation for Alcohol Research
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid-beta, Alzheimer's disease, hydroxysteroid dehydrogenase, neurotoxicity, neuronal dysfunction, amyloid-beta toxicity
- MeSH terms
- Alzheimer Disease, Amino Acid Sequence, Animals, Brain, Carrier Proteins, Cloning, Molecular, HeLa Cells, Humans, Hydroxysteroid Dehydrogenases, Molecular Sequence Data, Protein Binding, Recombinant Fusion Proteins, Transfection, 3-Hydroxyacyl CoA Dehydrogenases, Amyloid beta-Peptides, COS Cells
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