Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
Abstract
Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activation of the NMDA (N-methyl-D-aspartate) subtype of glutamate receptor, but LTP at hippocampal mossy fibre synapses is independent of NMDA receptors and has a component that is induced and expressed presynaptically. It appears to be triggered by a rise in presynaptic Ca2+, and requires the activation of protein kinase A, which leads to an increased release of glutamate. A great deal is known about the biochemical steps involved in the vesicular release of transmitter, but none of these steps has been directly implicated in long-term synaptic plasticity. Here we show that, although a variety of short-term plasticities are normal, LTP at mossy fibre synapses is abolished in mice lacking the synaptic vesicle protein Rab3A.
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Deletions of the corresponding Rab3 isoform in a synapse block long-term synaptic plasticity.
“deletions of the corresponding Rab3 isoform in a synapse appears to also block long-term synaptic plasticity”
From The Presynaptic Active Zone (2012) · cites this paper as Castillo et al., 1997
Rab3A mutant mice exhibit normal short-term plasticities but lack mossy fiber LTP.
“Interestingly, Rab3A mutant mice exhibit normal short-term plasticities but lack mossy fiber LTP (Castillo et al., 1997).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Castillo et al., 1997
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References 31 · Cited by 356
- Authors
- Castillo, P. E., Janz, R., Sdhof, T. C., Tzounopoulos, T., Malenka, R. C., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Nicoll, Roger A.
- Venue
- Nature
- Published
- 1997-08-07
- Volume
- 388
- Issue
- 6642
- Pages
- 590-593
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1483422351
- Cited by
- 356
- References
- 31
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 2 · 2015: 8 · 2014: 13 · 2013: 8 · 2012: 11
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- Rab3A, mossy fiber synapses, long-term potentiation, hippocampus, synaptic vesicle proteins, presynaptic plasticity, protein kinase A, glutamate release, synaptic plasticity
- MeSH terms
- Animals, Hippocampus, Immunoenzyme Techniques, Nerve Fibers, Nerve Tissue Proteins, Synapses, Long-Term Potentiation, Mice, Knockout, GTP-Binding Proteins, rab3 GTP-Binding Proteins, Mice, In Vitro Techniques
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