The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Functional regeneration after laser axotomy
Abstract
Understanding how nerves regenerate is an important step towards developing treatments for human neurological disease, but investigation has so far been limited to complex organisms (mouse and zebrafish) in the absence of precision techniques for severing axons (axotomy). Here we use femtosecond laser surgery for axotomy in the roundworm Caenorhabditis elegans and show that these axons functionally regenerate after the operation. Application of this precise surgical technique should enable nerve regeneration to be studied in vivo in its most evolutionarily simple form.
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“In contrast, forward locomotion in these mutants or D-ablated worms is described either as wild type (Walthall et al., 1993; Yanik et al., 2004), or nearly wild type with a reduction in amplitude (McIntire et al., 1993b).”
From Gait Modulation in C. elegans: An Integrated Neuromechanical Model (2012) · cites this paper as Yanik et al., 2004
In the citing paper
“The function of D-class neurons can be knocked out through mutation of genes required in the GABA pathway (McIntire et al., 1993b), by targeted killing of D-class neurons (Walthall et al., 1993) and by laser axotomy (Yanik et al., 2004), yielding essentially the same so-called shrinker phenotype (Hodgkin, 1983) in all cases: When touched on the head, wild type worms will back up, whereas worms who”
From Gait Modulation in C. elegans: An Integrated Neuromechanical Model (2012) · cites this paper as Yanik et al., 2004
In the citing paper
“In fact, in every case where forward locomotion of GABA pathway defective worms was reported (McIntire et al., 1993b; Walthall et al., 1993; Yanik et al., 2004), the assay was performed on agar.”
From Gait Modulation in C. elegans: An Integrated Neuromechanical Model (2012) · cites this paper as Yanik et al., 2004
Citations
Cites
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Research works printed but not linked: 9
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Femtosecond laser micromachining in transparent materials
Gattass, R. R., & Mazur, E. (2008) · Nature Photonics · doi:10.1038/nphoton.2008.47 · Cited by 3,306
Ultrafast lasers—reliable tools for advanced materials processing
Sugioka, K., & Cheng, Y. (2014) · Light: Science & Applications · doi:10.1038/lsa.2014.30 · Cited by 1,545
Thermo‐plasmonics: using metallic nanostructures as nano‐sources of heat
Baffou, G., & Quidant, R. (2013) · Laser & Photonics Review · doi:10.1002/lpor.201200003 · Cited by 1,318
Mechanisms of femtosecond laser nanosurgery of cells and tissues
Vogel, A., Noack, J., Hüttman, G., & Paltauf, G. (2005) · Applied Physics B · doi:10.1007/s00340-005-2036-6 · Cited by 1,445
Finding function in novel targets: C. elegans as a model organism
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Metadata
- Authors
- Yanik, M. F., Cinar, H., Cinar, H. N., Chisholm, A. D., Jin, Y., & Ben-Yakar, A.
- Affiliations
- Stanford University (US)
- University of California, Santa Cruz (US)
- Howard Hughes Medical Institute (US)
- Venue
- Nature
- Published
- 2004-12-15
- Volume
- 432
- Issue
- 7019
- Pages
- 822-822
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2076188357
- Cited by
- 598
- References
- 0
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 15 · 2023: 21 · 2022: 15 · 2021: 30 · 2020: 38 · 2019: 23 · 2018: 20 · 2017: 25 · 2016: 37 · 2015: 21 · 2014: 24 · 2013: 35 · 2012: 45
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- nerve regeneration, axotomy, Caenorhabditis elegans, functional regeneration
- MeSH terms
- Animals, Axons, Larva, Locomotion, Motor Neurons, Nerve Regeneration, Neurosurgery, Caenorhabditis elegans, Axotomy, Laser Therapy
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