The DOI matches its Crossref record.
Synthetic biology’s first malaria drug meets market resistance
Open accessOverview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cited by
Sorted by citations
Items 101–144 of 144
Harnessing Plant Trichome Biochemistry for the Production of Useful Compounds
Tissier, A. F. (2018) · Wiley eBooks · doi:10.1002/9781118801512.ch14 · Cited by 3
Feasibility study plant extracts in Rwanda : Developing value chains in public private partnerships
Jongschaap, R. E. E., de Vos, C. H., & Jongsma, M. A. (2018) · doi:10.18174/450679 · Cited by 3
“However, the demand for malaria drugs soars (van Noorden, 2010), and synthetic malaria drug meets market resistance (Peplow, 2016).”
BackgroundKam, M. Y. Y., & Yap, W. S. P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/740167 · Cited by 3
Is a convivial synthetic biology possible?
Tarnowski, M. J., & Pansera, M. (2024) · Journal of Responsible Innovation · doi:10.1080/23299460.2024.2351233 · Cited by 2
Upadhyay, V., Li, H., He, J., Ocampo, B. E., Cook, S. P., Zhao, H., & Maranas, C. D. (2025) · ACS Synthetic Biology · doi:10.1021/acssynbio.4c00707 · Cited by 2
Malakar, P., Deb, A. R., Goodine, T., Robertson, M. J., & Oelgemöller, M. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160332-00181 · Cited by 2
Nature's Armamentarium against Malaria: Antimalarials and Their Semisynthetic Derivatives
Ismail, F. M. D. (2018) · doi:10.1002/9781119436713.ch13 · Cited by 2
Yeasts, Molecular and Therapeutic Applications
Macreadie, I. G. (2017) · Kirk-Othmer Encyclopedia of Chemical Technology · doi:10.1002/0471238961.yeasmacr.a01.pub2 · Cited by 2
Kalalagh, K. F., Rezaei, A., Hazrati, S., Nicola, S., Moradi, S., Dizaj, S. D., Tariverdizadeh, N., & Kashkooli, A. B. (2025) · Malaria Journal · doi:10.1186/s12936-025-05648-4 · Cited by 1
New Models of Drug Discovery and Development for Neglected Disease Populations
Wells, T. N. C., van Huijsduijnen, R. H., & Burrows, J. N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12302-9 · Cited by 1
Liu, S., Ferreira, J., Tian, D., Tang, Y., Liu, L., Yang, W. J., Liu, Z., & Tian, N. (2017) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c17-00927 · Cited by 1
Agrawal, A., Sharma, A., & Shukla, N. P. (2020) · Current Biotechnology · doi:10.2174/2211550109666200306130503 · Cited by 1
Terpenes, meroterpenoids, and artemisinin and SARS-CoV-2
Malak, N., Niaz, S., Nasreen, N., Khan, A. N., & Sarfaraz, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95047-3.00005-8 · Cited by 1
Complex and Surprising Dynamics in Gene Regulatory Networks
Chen, S., & Zaikin, A. A. (2020) · Springer eBooks · doi:10.1007/978-981-33-4033-6_12 · Cited by 1
Alam, P., & Balawi, T. A. (2021) · ROMANIAN BIOTECHNOLOGICAL LETTERS · doi:10.25083/rbl/26.2/2384.2395 · Cited by 1
“It is because of artemisinin and its competitive pathways which played an important role to transfer the carbon fluxes towards artemisinin biosynthesis (PEPLOW, 2016; ABDIN and ALAM, 2015) in A. annua L. plants.”
BackgroundBaiden, F., Malm, K., & Binka, F. N. (2021) · doi:10.1093/med/9780198816805.003.0073 · Cited by 1
Concluding Remarks and Perspectives
Huang, P., Hsung, R. P., Ma, Z., & Yao, Z. (2018) · Wiley eBooks · doi:10.1002/9781118940228.ch12
Samarasinghe, D. K. (2018) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.3691
“Even though the semisynthesis of ART has been successful industrially, ART extraction from A. annua is much more economically viable: the semi-synthetic ART costs US$350-400/kg vs. US$250/kg of the naturally extracted from A. annua (Peplow, 2016).”
BackgroundYap, W. S. P., & Kam, M. Y. Y. (2021) · Springer eBooks · doi:10.1007/978-3-030-58271-5_3
Wünschiers, R. (2021) · Springer eBooks · doi:10.1007/978-3-662-64081-4_6
Wünschiers, R. (2019) · Springer eBooks · doi:10.1007/978-3-662-59048-5_6
Yee, M. K. Y., & Yap, W. S. P. (2021) · Journal of Tropical Plant Physiology · doi:10.56999/jtpp.2021.13.1.12
Egielewa, P. E., Ngonso, F. B., Ike, O. F., & Globethics.net (2022) · Globethics.net eBooks · doi:10.58863/20.500.12424/4244416 · Cited by 1
Photochemical routes to artemisinin
Lancel, M., Tambosco, B., & Amara, Z. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837672301-00301
Chen, J., Wu, W., Ding, X., Zhang, D., Dai, C., Pan, H., Shi, P., Wu, C., Zhang, J., Zhao, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24587838
Ethical Aspects of Promises and Perils of Synthetic Biology
Kelam, I. (2024) · Emerald Group Publishing Limited eBooks · doi:10.1108/978-1-83797-635-520241007
Synthetic Biology in Drug Development and Beyond
Sato, A. K., & Riffle, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-62007-2_2 · Cited by 1
ABDULKADIR, L. G., ALIERO, A. A., Maishanu, H. M., & Abbas, A. Y. (2024) · Journal of Plant Development · doi:10.47743/jpd.2024.31.1.964
Analysis of the intrinsic value of life in the context of synthetic biology
Zhang, Y. L., Chen, Y., & Liao, B. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1536403
“In 2014, the pharmaceutical giant Sano fi further transformed the artemisinin precursors produced by yeast fermentation into artemisinin, thereby realizing the practical application of biopharmaceuticals (Peplow, 2016).”
Identifying a kinetic model for the acid-catalyzed sequence of the artemisinin partial synthesis
Schulze, M., Triemer, S., Schenkendorf, R., Seidel‐Morgenstern, A., & Krewer, U. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167770 · Cited by 2
“Alternatively, semi-synthetic routes for artemisinin production have been targeted to be industrialized [6–8]; these are based on the fermentative production of ART precursors.”
Marsafari, M., Azi, F., Dou, S., & Xu, P. (2023) · Figshare · doi:10.6084/m9.figshare.22611670
Chen, J., Wu, W., Ding, X., Zhang, D., Dai, C., Pan, H., Shi, P., Wu, C., Zhang, J., Zhao, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26642353
Chen, J., Wu, W., Ding, X., Zhang, D., Dai, C., Pan, H., Shi, P., Wu, C., Zhang, J., Zhao, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24587951
Chen, J., Wu, W., Ding, X., Zhang, D., Dai, C., Pan, H., Shi, P., Wu, C., Zhang, J., Zhao, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26642356
Chen, J., Wu, W., Ding, X., Zhang, D., Dai, C., Pan, H., Shi, P., Wu, C., Zhang, J., Zhao, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26642359
Wünschiers, R. (2026) · Springer eBooks · doi:10.1007/978-3-662-71410-2_6
Non-coding RNA: a new perspective on the regulation of secondary metabolites in medicinal plants
Zhang, S., Chen, S., & Zhang, L. (2026) · Molecular Horticulture · doi:10.1186/s43897-026-00259-2
“However, the high production costs of this method pose significant challenges to its industrial-scale application (Mark 2016).”
Negri, S., Pietrolucci, F., Ramos, C., Venco, A., Carlessi, M., Franchetti, B., Commisso, M., Avesani, L., & Guzzo, F. (2026) · Acta Horticulturae · doi:10.17660/actahortic.2026.1462.2
Transcriptional regulation: efficient genetic engineering tools for non-conventional yeasts
Haneef, S., Zhou, Y. J., & Bai, F. (2026) · FEMS Yeast Research · doi:10.1093/femsyr/foag032
“…successful heterogeneous biosynthesis of mammalian and plant natural products (NPs) like hydrocortisone (Kelly and Kelly 2003 ), artemisinic acid (Peplow 2016 ), resveratrol (Li et al. 2015 ), strictosidine (Brown et al. 2015 ), and (S)- reticuline (Pyne et al. 2020 ) are also produced using…”
Metadata
- Authors
- Peplow, M.
- Venue
- Nature
- Published
- 2016-02-23
- Volume
- 530
- Issue
- 7591
- Pages
- 389-390
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2284539118
- Cited by
- 143
- References
- 0
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 18 · 2017: 23 · 2016: 6
- Type
- other
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Social Sciences › Business, Management and Accounting › Management of Technology and Innovation › Biotechnology and Related Fields
- Keywords
- malaria drugs, recombinant yeast, synthetic biology, drug production, commercialization, market resistance
- MeSH terms
- Antimalarials, Humans, Malaria, Drug Costs, Crops, Agricultural, Artemisia annua, Artemisinins, Synthetic Biology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review