Society must seize control of the antibiotics crisis
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Various commercially available antimicrobial drugs exhibit prominent defects, including nonspecific targeting and low concentrations in the lesion, leading to low efficiency, high toxicity, various side effects and multidrug resistance.
“At present, various commercially available antimicrobial drugs exhibit some prominent defects, including nonspecific targeting and low concentrations in the lesion, which leads to low efficiency, high toxicity, various side effects15 and multidrug resistance.16,17”
From Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach (2022) · cites this paper as [15]
The passage labelled Abstract (page not provided) says antibiotic resistance is growing and that more multiresistant bacteria are emerging. It does not link multidrug resistance to nonspecific targeting or low drug concentrations at lesions, and it does not discuss the claimed efficiency or toxicity defects. (LLM, conf=0.83)
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Zhang, X., Li, S., Luo, H., He, S., Yang, H., Li, L., Tian, T., Han, Q., Ye, J., Huang, C., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01035-6 · Cited by 14 · see citing works
- Authors
- Amábile-Cuevas, C.
- Corresponding author
- Amábile-Cuevas, Carlos
- Venue
- Nature
- Published
- 2016-05-25
- Volume
- 533
- Issue
- 7604
- Pages
- 439-439
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2404631572
- Cited by
- 33
- References
- 0
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 9 · 2017: 3 · 2016: 2
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- antibiotic resistance, drug development, public pressure, pharmaceutical industry, resistant infections, public health policy
- MeSH terms
- Medical Overuse, Drug Industry, Drug Resistance, Microbial, United Kingdom, Health Policy, Humans, Punishment, Reward, Drug Discovery, Inappropriate Prescribing
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